Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

YB-1 is a key regulator of the androgen receptor and androgen-responsive genes in prostate cancer cells [siRNA driven YB-1 knockdown]

ABSTRACT: YB-1 is a key regulator of the androgen receptor and androgen-responsive genes in prostate cancer cells [siRNA driven YB-1 knockdown]

PROVIDER: PRJNA515891 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

YB-1 knock.down - siRNA driven YBX1 knock.down

Project description:The transcription factor and RNA-interacting Y-box binding protein-1 (YB-1 protein, YBX1 gene) has gained interest as a prognostic biomarker and therapeutic target in various malignancies including prostate cancer. Using a custom prostate-cancer-focussed microarray platform, we have established a transcriptome-wide profile of YB-1 target transcripts in the androgen sensitive prostate cancer cell line LNCaP, including RNAs regulated by YB-1 at the post-transcriptional level; under androgen deprived culture conditions and following stimulation with dihydrotestosterone (DHT).

2022-01-17 | GSE125339 | GEO

YB-1 is a key regulator of the androgen receptor and androgen-responsive genes in prostate cancer cells

Project description:YB-1 is a key regulator of the androgen receptor and androgen-responsive genes in prostate cancer cells

| PRJNA515890 | ENA

YB-1 RIP.chip - Co-immunoprecipitation of RNAs present in YB-1 containing RNP granules

2022-01-17 | GSE125337 | GEO

YB-1 is a key regulator of the androgen receptor and androgen-responsive genes in prostate cancer cells [RIP - RNA immunoprecipitation of RNAs in YB-1 containing RNP granules]

Project description:YB-1 is a key regulator of the androgen receptor and androgen-responsive genes in prostate cancer cells [RIP - RNA immunoprecipitation of RNAs in YB-1 containing RNP granules]

| PRJNA515893 | ENA

YB-1 is a key regulator of the androgen receptor and androgen-responsive genes in prostate cancer cells [Transcriptome changes upon DHT stimulation]

Project description:YB-1 is a key regulator of the androgen receptor and androgen-responsive genes in prostate cancer cells [Transcriptome changes upon DHT stimulation]

| PRJNA515892 | ENA

Transcriptomic profile of YB-1 regulated downstream targets in prostate cancer cells

2022-01-17 | GSE125341 | GEO

Effects of YB-1 protein reduction on microRNA abundance in breast cancer cell-lines

Project description:To assess the association of the nucleic acid binding protein yb-1 with mature microRNAs levels in breast cancer. To do this we performed YB-1 siRNA treatement in triplicates alongside an siRNA control Two breast cancer cell-lines, representative of Luminal A and Basal molecular subtypes were used, MCF7 and MDA-MB-435S.

2014-01-23 | GSE50087 | GEO

Transcriptome changes upon androgen deprivation and DHT stimulation

2022-01-17 | GSE125338 | GEO

Somatic Primary piRNA Biogenesis Driven by Cis-Acting RNA Elements and Trans- Acting Yb

Project description:Primary piRNAs in Drosophila ovarian somatic cells arise from piRNA cluster transcripts and the 3′ UTRs of a subset of mRNAs, including Traffic jam (Tj) mRNA. However, it is unclear how these RNAs are determined as primary piRNA sources. Here, we identify a cis-acting 100-nt fragment in the Tj 3′ UTR that is sufficient for producing artificial piRNAs from unintegrated DNA. These artificial piRNAs were effective in endogenous gene transcriptional silencing. Yb, a core component of primary piRNA biogenesis center Yb bodies, directly bound the Tj-cis-element. Disruption of this interaction markedly reduced piRNA production. Thus, Yb is the trans-acting partner of the Tj-cis-element. Yb-CLIP revealed that Yb-binding correlated with somatic piRNA production but Tj-cis-element downstream sequences produced few artificial piRNAs. Thus, Yb determines primary piRNA sources by two modes of action; primary binding to cis-elements to specify substrates, and secondary binding to downstream regions to increase diversity in piRNA populations. HITS-CLIP of Yb in OSCs (Ovarian Somatic Cells) depleted for tj cis-element, and small RNA sequencing of Piwi-piRNAs in OSCs depleted for tj cis-element.

2015-06-05 | E-GEOD-69625 | biostudies-arrayexpress

Effect of PKN1 inhibition on androgen responsive genes.

Project description:To study and compare the effect of siRNA-mediated PKN1 silencing and CEP701-mediated PKN1 inhibition on androgen-responsive genes.

2017-04-08 | GSE97398 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data