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Analysing the gene expression between wildtype and Nxt1 trans-heterozygotes in whole larvae

ABSTRACT: Analysing the gene expression between wildtype and Nxt1 trans-heterozygotes in whole larvae

PROVIDER: PRJNA517495 | ENA |

REPOSITORIES: ENA

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Analysing the gene expression between wildtype and Nxt1 trans-heterozygotes in whole larvae

Project description:We used whole larvae of both wildtype and Nxt1 trans-heterozygotes for RNA paired-end sequencing and obtained a read depth between 6.4M to 11.1M reads across all samples. In wandering larvae, stationary larvae and white prepupae, a total of 435, 855, and 611 genes were differentially expressed. A high percentage of down-regulated genes were highly expressed/testis-specific in the Drosophila testis.

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Analysing the gene expression between wildtype and Nxt1 trans-heterozygotes in larval carcasses

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Analysing the gene expression between wildtype and Nxt1 trans-heterozygotes in larval carcasses

Project description:We used larval carcasses of both wildtype and Nxt1 trans-heterozygotes for RNA paired-end sequencing and obtained a read depth between 21M to 32M reads across all samples. A total of 1821 genes were down-regulated and 1339 genes were up-regulated. A python script extracting intron data of genes from the FlyMine database identified a trend where down-regulated genes had a higher total intron length and had more introns. Up-regulated genes had a lower total intron length and less introns when compared to the non-differentially expressed genes. Furthermore, down-regulated genes showed that the majority of genes are involved in the production of circular RNAs

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