Project description:Methanothermobacter thermautotrophicus is a model thermophilic hydrogenotrophic methanogen. The life and survival of M. thermautotrophicus is highly influenced by the availability of nutrients and temperature. To learn about adaptation mechanisms evolved by the archaea to cope with drastic temperature shifts, the responses of model M. thermautotrophicus ΔH to temperature were investigated using a quantitative proteomics approach with iTRAQ-LC-MS/MS.