Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Extensive tissue-specific, circadian molecular variation in a Drosophila Genetic Reference Panel

ABSTRACT: Extensive tissue-specific, circadian molecular variation in a Drosophila Genetic Reference Panel

PROVIDER: PRJNA518903 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Extensive tissue-specific, circadian molecular variation in a Drosophila Genetic Reference Panel

Project description:We report a large-scale transcriptomic analysis of several tissues of a reference Drosophila melanogaster strain as well as 141 Drosophila Genetic Reference Panel (DGRP) lines at high temporal resolution. Comprehensive data analysis has identified thousands of genes under clock- and tissue-specific control. By using a molecular time table approach, we uncovered that >20% of probed DGRP lines exhibit aberrant circadian expression, and the genetic dissection of one line (DGRP-796) revelled disrupted circadian gene expression in all analysed tissues, revealing a novel deletion in the cry gene. Together, this study revealed extensive variation in tissue-specific circadian expression, which acts upon tissue-specific regulatory networks to generate local oscillations in gene expression. Moreover, the many other lines identified here can be now used to better understand the mechanisms underlying the molecular clock, from tissue-specific to more central mechanisms.

2020-12-10 | GSE126018 | GEO

PAGE: Global Reference Panel

Project description:PAGE: Global Reference Panel

| PRJNA302341 | ENA

Gene Expression Networks in the Drosophila Genetic Reference Panel

Project description:A major challenge of modern biology is to understand how naturally occurring variation in DNA sequences affects complex organismal phenotypes through networks of intermediate molecular phenotypes. Here, we performed deep RNA sequencing of 200 Drosophila Genetic Reference Panel inbred lines with complete genome sequences and mapped expression quantitative trait loci for annotated genes, novel transcribed regions (most of which are long noncoding RNAs), transposable elements and microbial species. We identified host variants affecting expression of transposable elements independent of copy number and microbiome composition. We constructed sex-specific expression quantitative trait locus regulatory networks. These networks are enriched for novel transcribed regions and target genes in heterochromatin and euchromatic regions of reduced recombination and are associated with transposable element expression. This study uncovers novel genetic features that regulate natural genetic variation of gene expression and generates testable hypotheses for future functional analyses.

2020-02-28 | GSE117850 | GEO

Wing disc transcriptomic variation from 32 Drosophila genetic reference panel (DGRP) lines selected for a broad range of wing sizes

Project description:We performed RNA sequencing of wing discs at the wandering L3 larval stage from 32 inbred lines of Drosophila genetic reference panel (DGRP) that consists of 16 big and 16 small wing lines. We aimed to understand system-wide gene regulatory mechanisms that attain the observed natural variation in wing size including the sexual size dimorphism.

2019-02-18 | E-MTAB-7662 | biostudies-arrayexpress

Gene Expression Networks in the Drosophila Genetic Reference Panel

Project description:Gene Expression Networks in the Drosophila Genetic Reference Panel

| PRJNA483441 | ENA

Effects of extensive fasting on hepatic transcription

2009-11-23 | GSE13064 | GEO

Human Variation Panel: Gene Expression and Genotype

Project description:This SuperSeries is composed of the following subset Series: GSE23120: Basal gene expression data from Human Variation Panel GSE24245: Genome-wide SNP array data from Human Variation Panel by Illumina 510S GSE24260: Genome-wide SNP array data from Human Variation Panel by Illumina 550K GSE24274: Genome-wide SNP array data from Human Variation Panel by Illumina 650K Refer to individual Series

2010-09-24 | E-GEOD-24277 | biostudies-arrayexpress

The genetic basis for variation in resistance to infection in the Drosophila melanogaster genetic reference panel.

Project description: Not available

| S-EPMC5352145 | biostudies-literature

cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel.

Project description: Not available

| S-EPMC6966807 | biostudies-literature

Effects of extensive fasting on hepatic transcription

Project description:Temporally restricted feeding has a profound effect on the hepatic circadian clock. While the circadian clock is largely unaffected by by extensive fasting, many transcripts are known to be affected by a fasting paradigm. This dataset shows the effect of extensive fasting on dynamic gene expression in the liver C57/B6 mice were entrained to ad libitum feeding schedule for two weeks. They were then released into constant were food was withdrawn at CT16. On the second day in constant darkness tissue was collected at the indicated timepoints. Total RNA was extracted and 5ug of total RNA was used for the standard Affymetrix protocol of amplification, labeling and hybridization

2009-11-23 | E-GEOD-13064 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data