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RNA-Seq analysis in liver tissues of Wild Type and Ezh2(K307R) mice.

ABSTRACT: RNA-Seq analysis in liver tissues of Wild Type and Ezh2(K307R) mice.

PROVIDER: PRJNA521876 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR8564970.fastq.gz	Fastqsanger.gz
	SRR8564967.fastq.gz	Fastqsanger.gz
	SRR8564968.fastq.gz	Fastqsanger.gz
	SRR8564969.fastq.gz	Fastqsanger.gz

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RNA-Seq analysis in liver tissues of Wild Type and Ezh2(K307R) mice.

Project description:RNA-Seq analysis in liver tissues of Wild Type and Ezh2(K307R) mice.

| PRJNA521876 | ENA

RNA-Seq analysis in liver tissues of Wild Type and Ezh2(K307R) mice.

Project description:The histone methyl transferase EZH2, a member of PRC2, is a master epigenetic regulator involved in histone H3 lysine 27 trimethylation and gene transcription repression. Here, we reported the K307 dimethylation of EZH2 could regulate its protein stability. Thus, to further investigate the biological significance of the K307 dimethylation of EZH2 and to explore its downstream regulated genes, we subsequently analyzed the genome-wide transcriptional targets of Ezh2K307R using an RNA sequencing (RNA-seq) approach in the livers of Ezh2K307R and WT mice.

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Lysine methylome features in EZH2 wild-type and mutant lymphoma cell line

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Project description:To investigate the role of METTL3-mediated m6A modification in liver, we performed m6A-sequencing and RNA-seq to map the m6A modification and gene expression in liver tissues or hepatocytes of wild type (WT) and liver-sepcific Mettl3-KO mice.

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