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Expression data from germ cell tumor patient-derived cells

ABSTRACT: Expression data from germ cell tumor patient-derived cells

PROVIDER: PRJNA527840 | ENA |

REPOSITORIES: ENA

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Expression data from germ cell tumor patient-derived cells

Project description:Patient-derived cancer cells (PDCs) were established by three-dimensional (3D) spheroid culture from testicular germ cell tumor (GCT) specimens. Microarray expression analysis revealed that cancer stem-like cell-related genes were upregulated in 3D culture condition compared with two-dimensional (2D) culture condition.

2022-03-18 | GSE128491 | GEO

Gene expression profile in patient-derived ameloblastoma tumor

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Gene expression profiles of a non-gestational choriocarcinoma and its corresponding patient-derived xenograft tumor

Project description:Non-gestational choriocarcinoma (NGC) is a rare subtype of malignant germ cell tumor. We established a patient-derived xenograft (PDX) model using tumor tissue from an 18-year-old patient with NGC. Then, we performed mRNA-seq analysis using the fresh-frozen tissues of the original tumor and the PDX model.

2023-05-03 | GSE230352 | GEO

Expression data from testicular germ cell tumor cells

Project description:To clarify the mechanism of cisplatin resistance in testicular germ cell tumor (TGCT), cisplatin-resistant TGCT cells (N8R and G9R) were generated from parental NEC8 cells (N8P) and TGCT patient-derived cells (TGCT-PDC)(G9P), respectively, by culture in medium containing cisplatin. We used microarrays to detail the global programme of gene expression underlying cisplatin resistance and identified up- and down-regulated genes during this process.

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Gene expression data comparing Wilms tumor primary samples to patient-derived xenografts

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Molecular variability of patient-derived colon tumor xenografts

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Comparing Wilms tumor primary samples to patient-derived xenografts

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DNA methylation data comparing Wilms tumor primary samples to patient-derived xenografts

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Gene expression data comparing Wilms tumor primary samples to patient-derived xenografts

Project description:The lack of model systems limits the preclinical testing of novel therapies to address Wilms tumor patient groups with poor outcomes. Therefore, we established 45 heterotopic Wilms tumor patient-derived xenografts (WTPDX) in CB17 scid-/- mice that capture the biological heterogeneity of Wilms tumor (WT). These WTPDX include six showing diffuse anaplasia, nine from patients who went on to experience disease relapse, and thirteen from patients with bilateral disease. WTPDX retained the genetic alterations and the global transcriptomic and methylation profile of corresponding primary WT. In addition, favorable histology WTPDX were chemosensitive, while unfavorable histology WTPDX were resistant to conventional chemotherapy with vincristine, actinomycin-D, and doxorubicin. This WTPDX library is a unique scientific resource that retains the spectrum of biological heterogeneity present in WT and provides an essential tool for the testing of novel targeted therapies in the era of precision medicine.

2019-02-14 | GSE110696 | GEO

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