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Chromothripsis is a prognostic factor in early-onset breast cancer [OncoScan]

ABSTRACT: Chromothripsis is a prognostic factor in early-onset breast cancer [OncoScan]

PROVIDER: PRJNA528213 | ENA |

REPOSITORIES: ENA

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Chromothripsis is a prognostic factor in early-onset breast cancer [OncoScan]

Project description:Breast cancer in Spain remains the first leading cause of cancer-related death in women from all age, and in younger women breast tumors often exhibit more aggressive phenotypes, worse prognosis and more frequently germline mutation in BRCA1/2 genes. Chromothripsis, a massive genome rearrangement, has been recently described but its etiology and effect on cancer cells remain unknown. Chromothripsis in breast cancer has been poorly studied and prevalence rates vary between 11-61%. We have studied chromothripsis-like patterns (CTLPs) in 58 DNA extracted from formalin-fixed paraffin-embedded (FFPE) breast cancer tissues from patients below 40 years old. Chromothripsis was confirmed with website tool CTLPScanner in 10/58 (17%) and most frequently involved chromosomal segment was 17q12-q21 (5/10 cases, 50%). We have also find that chromothripsis was related to low recurrence rates and familial history of breast cancer. In summary, we have analyzed chromothripsis in early-onset breast cancer for the first time and could have a prognostic value for this patients

2021-03-31 | GSE128584 | GEO

Chromothripsis is a prognostic factor in early-onset breast cancer [OncoScan_CNV]

2021-03-31 | GSE128586 | GEO

Chromothripsis is a prognostic factor in early-onset breast cancer [CytoScan750K_Array]

2021-03-31 | GSE128583 | GEO

Chromothripsis is a prognostic factor in early-onset breast cancer

Project description:Chromothripsis is a prognostic factor in early-onset breast cancer

| PRJNA528208 | ENA

Chromothripsis is a prognostic factor in early-onset breast cancer [OncoScan_CNV]

Project description:Chromothripsis is a prognostic factor in early-onset breast cancer [OncoScan_CNV]

| PRJNA528214 | ENA

Chromothripsis is a prognostic factor in early-onset breast cancer [CytoScan750K_Array]

Project description:Chromothripsis is a prognostic factor in early-onset breast cancer [CytoScan750K_Array]

| PRJNA528200 | ENA

Chromothripsis is a prognostic factor in early-onset breast cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-03-31 | GSE128587 | GEO

Oncoscan for HER2 copy number assessment

Project description:Affymetrix Oncoscan arrays were performed according to the manufacturer's directions on DNA extracted from FFPE-breast cancer tissues. Copy number analysis using Affymetrix Oncoscan arrays was performed for 29 primary breast cancers

2016-07-01 | E-GEOD-83916 | biostudies-arrayexpress

chromothripsis in neuroblastoma

Project description:chromothripsis in neuroblastoma

| PRJEB671 | ENA

Oncoscan for HER2 copy number assessment

Project description:Affymetrix Oncoscan arrays were performed according to the manufacturer's directions on DNA extracted from FFPE-breast cancer tissues.

2016-07-01 | GSE83916 | GEO

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