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Analysis of mRNA expression changes caused by mdt-15(tm2182) mutation at 15oC and 25 oC

ABSTRACT: Analysis of mRNA expression changes caused by mdt-15(tm2182) mutation at 15oC and 25 oC

PROVIDER: PRJNA528939 | ENA |

REPOSITORIES: ENA

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Analysis of mRNA expression changes caused by mdt-15(tm2182) mutation at 15oC and 25 oC

Project description:To determine the role of MDT-15 in mRNA expression changes at different temperatures, we sequenced mRNAs obtained from day 1 adult Caenorhabditis elegans. Bristol N2 (wild-type) and mdt-15(tm2182) mutant animals that cultured at 25oC or 15oC were used.

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Panicum virgatum cultivar:SAP-25-15

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Expression data from human OC+BAP+ double positive versus OC-BAP- double negative cells

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Expression data from OL and OC treated B16F10 cells

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Expression data from Orange cells (BT-OC) -treated HFDPCs

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Real-time quantitative PCR analysis of celecoxib treatment on OC tissue chip

Project description:To test the utility of iPSC-derived OC tissue chip in drug screening, Celecoxib, a selective cyclooxygenase 2 (COX-2) inhibitor commonly used to treat OA, was administered to the system. Celecoxib was administered at 10 µM concentration, and showed no noticeable adverse effect on the health of normal chondral tissue. Administration of Celecoxib to both OC-C and OC-B were used to simulate the typically systemic action of Celecoxib, represented by the “SY” group. In addition, we also examined the potential effect of intraarticular (IA) application of Celecoxib in treating OA, by delivery only to OC-C, namely the “IA” group. Normal OC tissues without any treatments served as the control (CL).

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An innate IL-25-ILC2-MDSC axis creates a cancer-permissive microenvironment for Apc-mutation-driven intestinal tumorigenesis

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