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Antidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive-like behavior

ABSTRACT: Antidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive-like behavior

PROVIDER: PRJNA531007 | ENA |

REPOSITORIES: ENA

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Antidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive-like behavior

Project description:Accumulating evidence demonstrates that the gut microbiota affects brain function and behavior, including depressive behavior. Antidepressants are the main drugs used for treatment of depression. We hypothesized that antidepressant treatment could modify gut microbiota which can partially mediate their antidepressant effects. Mice were chronically treated with one of five antidepressants (fluoxetine, escitalopram, venlafaxine, duloxetine or desipramine), and gut microbiota was analyzed, using 16s rRNA gene sequencing. After characterization of differences in the microbiota, chosen bacterial species were supplemented to vehicle and antidepressant-treated mice, and depressive-like behavior was assessed to determine bacterial effects. RNA-seq analysis was performed to determine effects of bacterial treatment in the brain. Antidepressants reduced richness and increased beta diversity of gut bacteria, compared to controls. At the genus level, antidepressants reduced abundances of Ruminococcus, Adlercreutzia, and an unclassified Alphaproteobacteria. To examine implications of the dysregulated bacteria, we chose one of antidepressants (duloxetine) and investigated if its antidepressive effects can be attenuated by simultaneous treatment with Ruminococcus flavefaciens or Adlercreutzia equolifaciens. Supplementation with R. flavefaciens diminished duloxetine-induced decrease in depressive-like behavior, while A. equolifaciens had no such effect. R. flavefaciens treatment induced changes in cortical gene expression, up-regulating genes involved in mitochondrial oxidative phosphorylation, while down-regulating genes involved in neuronal plasticity. Our results demonstrate that various types of antidepressants alter gut microbiota composition, and further implicate a role for R. flavefaciens in alleviating depressive-like behavior.

2019-04-05 | GSE129359 | GEO

Expression profiling of Ruminococcus flavefaciens FD-1 with growth on cellulose or cellobiose

Project description:This study compares growth of Ruminococcus flavefaciens FD-1 with cellulose or cellobiose as the carbohydrate substrate. Ruminococcus flavefaciens is a predominant cellulolytic rumen bacterium, which forms a multi-enzyme cellulosome complex that could play an integral role in the ability of this bacterium to degrade plant cell wall polysaccharides. Identifying the major enzyme types involved in plant cell wall degradation is essential for gaining a better understanding of the cellulolytic capabilities of this organism as well as highlighting potential enzymes for application to improvement of livestock nutrition and for conversion of cellulosic biomass to liquid fuels. These results show that the growth substrate drives expression of enzymes predicted to be involved in carbohydrate metabolism as well as expression and assembly of key cellulosomal enzyme components. 1 species (Ruminococcus flavefaciens FD_1), 2 conditions (cellulose, cellobiose), 4 biological replicates. Direct design with biological dye swap.

2010-05-16 | E-GEOD-15916 | biostudies-arrayexpress

Expression profiling of Ruminococcus flavefaciens FD-1 with growth on cellulose or cellobiose

2009-06-29 | GSE15916 | GEO

Ruminococcus flavefaciens

Project description:Ruminococcus flavefaciens overview

| PRJNA38071 | ENA

Antidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive-like behavior.

Project description: Not available

| S-EPMC6456569 | biostudies-literature

Lanthipeptides from Ruminococcus flavefaciens FD-1

Project description:Paper title: Production of lantibiotics from the anaerobe Ruminococcus flavefaciens FD-1 in Escherichia coli Author list: Zhao, X, van der Donk W. A. Citation: Chemistry & Biology, accepted. Brief description of data: Fragmentation data of heterologously expressed lanthipeptides from Ruminococcus flavefaciens FD-1. Full length, modified peptides were cleaved with Glu-C or chymotrypsin and purified by reverse phase HPLC prior to analysis.

2015-12-25 | MSV000079434 | MassIVE

Ruminococcus flavefaciens strain:y1

Project description:Ruminococcus flavefaciens Y1 genome sequencing

| PRJNA303327 | ENA

Ruminococcus flavefaciens strain:xpd3002

Project description:Ruminococcus flavefaciens XPD3002 genome sequencing

| PRJNA303263 | ENA

Ruminococcus flavefaciens ND2009

Project description:Ruminococcus flavefaciens ND2009 Genome sequencing and assembly

| PRJNA223442 | ENA

Ruminococcus flavefaciens AE3010

Project description:Ruminococcus flavefaciens AE3010 Genome sequencing and assembly