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High-temporal-resolution transcriptome analysis of the anti-IgM-stimulated mouse B cells

ABSTRACT: High-temporal-resolution transcriptome analysis of the anti-IgM-stimulated mouse B cells

PROVIDER: PRJNA531688 | ENA |

REPOSITORIES: ENA

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High-temporal-resolution transcriptome analysis of the anti-IgM-stimulated mouse B cells

Project description:B cell receptor (BCR) is essential in activating B cells and mediating the immune responses. Analyzing the BCR-triggered gene expression would help delineate the regulatory function of B cells. The mouse B cells were treated with anti-IgM mAb to mimic the BCR stimulation, and the genome-wide transcriptional responses were analyzed by using high-throughput sequencing at high-temporal resolution (24 time points over 6 hours).

2019-04-10 | GSE129536 | GEO

WT and Ikaros-deficient follicular B cells stimulated with anti-IgM

Project description:We have observed that follicular B cells from mice with a hypomorphic mutation (IkL/L) in the Ikzf1 gene (which encodes the Ikaros transcription factor) exhibit an increased proliferative response to anti-IgM stimulation (Kirstetter et al, Eur J Immunol, 32:720-30, 2002). We asked if Ikaros controls the transcriptional response that unfolds after activation, or if differences in the transcriptional landscape of resting B cells could explain the altered response. To this end, we have determined the transcriptome of unstimulated WT and IkL/L follicular B cells, as well as that of cells stimulated for 3h and 12h with anti-IgM. Samples from 2 independent experients were analyzed. Follicular splenic B cell were sorted from 6-week old WT or IkL/L mice, and stimulated for 3 or 12h with anti IgM, or cultured without anti-IgM for 3h (unstimulated samples) 2 independant experiments were performed

2016-01-26 | E-GEOD-75712 | biostudies-arrayexpress

B cell response to Anti-IgM and terbutaline treatment

Project description:Temporal analysis (60, 180, 360 min) of B cells treated with Anti-IgM alone, terbutaline alone or Anti-IgM and terbutaline (all in triplicates). Keywords: other

2004-02-13 | GSE1021 | GEO

B cell response to Anti-IgM and ELC treatment

Project description:Temporal analysis (60, 180, 360 min) of B cells treated with Anti-IgM alone, ELC alone or Anti-IgM and ELC (all in triplicates). Keywords: other

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B cell response to Anti-IgM and CD40 treatment

Project description:Temporal analysis (60, 180, 360 min) of B cells treated with Anti-IgM alone, CD40 alone or Anti-IgM and CD40 (all in triplicates). Keywords: other

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WT and Ikaros-deficient follicular B cells stimulated with anti-IgM

2016-01-26 | GSE75712 | GEO

B cell response to CD40, Anti-IgM, ELC, IL4, terbutaline and lipopolysaccharide treatment

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Gene expression in anti-IgM IFNg treated B cells

Project description:RNAseq data of human naive B cells untreated or stimulated with anti-IgM and IFNg

2021-08-11 | GSE181739 | GEO

B cell response to CD40, Anti-IgM, ELC, IL4, terbutaline and lipopolysaccharide treatment

Project description:Temporal analysis (60, 180, 360 min) of B cells treated with either: CD40 Anti-IgM ELC IL4 Lipopolysaccharide Terbutaline CD40 and IL4 CD40 and Lipopolysaccharide CD40 and Anti-IgM Anti-IgM and ELC Anti-IgM and Terbutaline ELC and Lipopolysaccharide This SuperSeries is composed of the following subset Series: GSE1019: B cell response to Anti-IgM and CD40 treatment GSE1020: B cell response to Anti-IgM and ELC treatment GSE1021: B cell response to Anti-IgM and terbutaline treatment GSE1022: B cell response to CD40 and lipopolysaccharide treatment GSE1023: B cell response to CD40 and IL4 treatment GSE1024: B cell response to ELC and lipopolysaccharide treatment Refer to individual Series

2010-06-09 | E-GEOD-1014 | biostudies-arrayexpress

Genome-wide expression analysis of genes regulated in primary human B cell and PBMC co-cultures stimulated with anti-IgM and superantigens

Project description:Illumina microarray analysis of primary human B cell and peripheral blood mononuclear cell (PBMC) co-cultures stimulated with anti-IgM and superantigens for 3 days (BT) compared to the same co-cultures without stimualtion (BTNo). Total RNA was extracted from co-cultures after 3 days in the presence or absence of stimulation with anti-IgM and superantigens.

2012-12-26 | E-GEOD-42567 | biostudies-arrayexpress

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