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Critical Role of Jumonji Domain of JMJD1C in MLL-rearranged leukemia

ABSTRACT: Critical Role of Jumonji Domain of JMJD1C in MLL-rearranged leukemia

PROVIDER: PRJNA532423 | ENA |

REPOSITORIES: ENA

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Critical role of Jumonji domain of JMJD1C in MLL-rearranged leukemia.

Project description: Not available

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RNA-seq study on MLL-AF9 leukemia cells harboring JMJD1C sgRNAs targeting jumonji and zinc finger domains.

Project description:We transduced clonally MLL-AF9 leukemia cells expressing cas9 with sgRNA targeting the jumonji and zinc finger domains of JMJD1C. GFP (MLL-AF9) and TdTomato (sgRNA) double positive cells were sorted on Day 6 after transduction. Total RNA was isolated followed by mRNA selection. cDNA libraries were generated and NextGen Sequencing was performed.

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Single-cell sequencing of JMJD1C Jumonji domain mutated MLL-AF9 Leukemia cells

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Single-cell sequencing of JMJD1C Jumonji domain mutated MLL-AF9 Leukemia cells

Project description:Single-cell sequencing of JMJD1C Jumonji domain mutated MLL-AF9 Leukemia cells

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ChIP-seq of histone marks H3K36, H3K27, and H3K9 in JMJD1C knockout or mutated MLL-AF9 leukemia cells

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Critical Role of Jumonji Domain of JMJD1C in MLL-rearranged leukemia

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-04-12 | GSE129675 | GEO

Effect of loss of Jmjd1c on MLL-AF9 leukemia

Project description:Analysis of gene expression profile of MLL-AF9 leukemia cells 6 days after loss of Jmjd1c. Loss of Jmjd1c induces differentiation and apoptosis in MLL-AF9 leukemia cells. These results provide insight into the role of Jmjd1c in MLL leukemia.

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shRNA Screening Identifies JMJD1C as being required for Leukemia Maintenance (Agilent)

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shRNA Screening Identifies JMJD1C as being required for Leukemia Maintenance

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shRNA Screening Identifies JMJD1C as being required for Leukemia Maintenance (Agilent)

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