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Re-configuration of Chromatin Structure During the Mitosis-G1 Phase Progression

ABSTRACT: Re-configuration of Chromatin Structure During the Mitosis-G1 Phase Progression

PROVIDER: PRJNA533460 | ENA |

REPOSITORIES: ENA

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Re-configuration of Chromatin Structure During the Mitosis-G1 Phase Progression

Project description:Chromatin architecture is temporarily disrupted during mitosis. Yet, how chromatin architecture is reconfigured during M-G1 phase transition is unknown. To examine this, we performed Hi-C experiments on cell populations at defined cell cycle stages between mitosis and G1 phase.

2019-11-27 | GSE129997 | GEO

CTCF and transcription orchestrate chromatin structure re-configuration after mitosis [Hi-C]

Project description:During mitosis, transcription is globally attenuated and chromatin architecture is dramatically reconfigured. Here we exploited the M-phase to G1-phase progression to interrogate the contributions of the architectural factor CTCF and the process of transcription to re-sculpting the genome in newborn nuclei. While CTCF appears to be dispensable for large scale post-mitotic compartmentalization, depletion of CTCF specifically during the M-phase to G1-phase transition alters the re-establishment of local short-range compartmentalization after mitosis. Without CTCF, structural loops fail to reform, leading to illegitimate contacts between cis-regulatory elements (CREs) and altered gene expression in G1-phase. Transient CRE contacts that are normally resolved after telophase persist deeply into G1-phase in CTCF depleted cells. Boundary reformation is largely disrupted upon CTCF loss. Yet, a subset (~27%) of boundaries emerges normally in the absence of CTCF and is characterized by transitions in chromatin states. Reformation of gene domains can occur prior to the full onset of transcription and can be linked to tri-methylation at lysine 36 of histone 3 (H3K36me3), a mark stable throughout mitosis. The focus on the de novo formation of nuclear architecture during G1 entry yielded novel insights into how CTCF and the process of transcription contribute to the dynamic re-configuration of chromatin architecture during the mitosis to G1 phase progression.

2021-06-17 | GSE168176 | GEO

CTCF and transcription orchestrate chromatin structure re-configuration after mitosis [ChIP-seq]

2021-06-17 | GSE168168 | GEO

CTCF and transcription orchestrate chromatin structure re-configuration after mitosis

Project description:CTCF and transcription orchestrate chromatin structure re-configuration after mitosis

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CTCF and transcription orchestrate chromatin structure re-configuration after mitosis [ChIP-seq]

Project description:CTCF and transcription orchestrate chromatin structure re-configuration after mitosis [ChIP-seq]

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CTCF and transcription orchestrate chromatin structure re-configuration after mitosis [Hi-C]

Project description:CTCF and transcription orchestrate chromatin structure re-configuration after mitosis [Hi-C]

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H2A.Z Mapping During G0/G1 and Mitosis

Project description:We report genome wide mapping of the histone variant H2A.Z during G0/G1 and mitosis in T24 bladder cancer cells. The results show that the broad enrichment pattern of H2A.Z near transcription start sites of active genes is maintained during mitosis. Furthermore, using H2A.Z localization to visualize nucleosome positioning near the start site, we see that the +1 nucleosome of active genes shifts upstream to occupy the transcription start sites during mitosis and the nucleosome depleted region is shortened. H2A.Z is also maintained on the -2 nucleosome which also shifts towrds the transcription start site during mitosis, further contributing to the shorteneing of the nucleosome depleted region. Examination of H2A.Z duing G0/G1 and mitosis in bladder cancer cells

2010-06-24 | E-GEOD-19568 | biostudies-arrayexpress

H2A.Z Mapping During G0/G1 and Mitosis

2010-06-24 | GSE19568 | GEO

CTCF and transcription orchestrate chromatin structure re-configuration after mitosis

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-06-17 | GSE168251 | GEO

A hyperactive transcriptional state marks genome reactivation at the mitosis-G1 transition [CaptureC]

Project description:Capture-C of G1E ER4 cell line in a nocodazole arrest-release experiment anchored at multiple gene promoters to quantify long-range chromatin interactions at the mitosis-G1 transition.

2016-06-15 | GSE83290 | GEO

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