Project description:The mechanisms by which oscillatory shear (OS) induces, while high laminar shear stress (LS) prevents, atherosclerosis are still unclear. Here, we examined the hypothesis that OS induces inflammatory response, a critical atherogenic event, in endothelial cells by a miRNA-dependent mechanism. In particular, miR-663 mediated OS-induced inflammation through monocyte adhesion to endothelial cells. The potential targets of miR-663 were examined by knockdown of miR-663 and then the gene expression profiles were determined under shear stress conditions. To determine the potential targets of miR-663, HUVEC were transfected either with miR-663-LNA (inhibitor of miR-663) or control-LNA and then subjected to OS or LS for 24hr. Total RNA were collected from these four groups and microarray studies (Illumina HumanHT-12 v3 beadchip) were performed.

2011-03-10 | E-GEOD-20739 | biostudies-arrayexpress

Colletotrichum fioriniae strain:ATCC MYA-663 | isolate:ATCC MYA-663

Project description:Colletotrichum fioriniae ATCC MYA-663 Resequencing genome sequencing

| PRJNA333320 | ENA

Panicum virgatum cultivar:AP13xWBC3xDAC6xVS16 - 663

Project description:Panicum virgatum AP13xWBC3xDAC6xVS16 - 663 - Mapping Population genome sequencing

| PRJNA363197 | ENA

Aspergillus welwitschiae strain:CCMB 663

Project description:Aspergillus welwitschiae strain:CCMB 663 Assembly

| PRJNA435842 | ENA

Gammaproteobacteria bacterium SCGC AB-663-P10

Project description:Gammaproteobacteria bacterium SCGC AB-663-P10 Genome sequencing

| PRJNA234901 | ENA

Planctomycetes bacterium SCGC AB-663-N19

Project description:Planctomycetes bacterium SCGC AB-663-N19 Genome sequencing

| PRJNA195648 | ENA

Thaumarchaeota archaeon SCGC AB-663-F14

Project description:Thaumarchaeota archaeon SCGC AB-663-F14 Genome sequencing

| PRJNA195686 | ENA

Thaumarchaeota archaeon SCGC AB-663-O07

Project description:Thaumarchaeota archaeon SCGC AB-663-O07 Genome sequencing

| PRJNA195685 | ENA

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