Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Obesity Remodels Activity and Transcriptional State of a Lateral Hypothalamic Brake on Feeding

ABSTRACT: Obesity Remodels Activity and Transcriptional State of a Lateral Hypothalamic Brake on Feeding

PROVIDER: PRJNA540713 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Obesity Remodels Activity and Transcriptional State of a Lateral Hypothalamic Brake on Feeding

Project description:We demonstrate that high fat diet (HFD)-induced obesity alters the transcriptional state of lateral hypothalamic glutamate neurons in mice.

2019-05-02 | GSE130597 | GEO

Obesity remodels activity and transcriptional state of a lateral hypothalamic brake on feeding.

Project description: Not available

| S-EPMC7318865 | biostudies-literature

Molecular codes defining lateral hypothalamic sleep regulating neurons

Project description:Molecular codes defining lateral hypothalamic sleep regulating neurons

| PRJNA521659 | ENA

Molecular and Structural Bases of Hypothalamic Development

2014-12-19 | GSE64347 | GEO

Molecular and Structural Bases of Hypothalamic Development

Project description:To compare the global profile of hypothalamic gene expression in agonadal male infants before and after activation of the neurobiologic brake that arrests pulsatile GnRH release during the juvenile phase of development. Affymetrix arrays were used to detect global changes in gene expression in the hypothalamus of of the agonadal rhesus monkey during development.

2014-12-19 | E-GEOD-64347 | biostudies-arrayexpress

Fasting and feeding hormones differentially impact activity dynamics of transcriptionally distinct lateral hypothalamic glutamate projection neurons

Project description:Fasting and feeding hormones differentially impact activity dynamics of transcriptionally distinct lateral hypothalamic glutamate projection neurons

| PRJNA715479 | ENA

Single cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons

Project description:We employed a droplet-based single cell RNA-sequencing (scRNA-seq) approach to develop a comprehensive census of molecularly distinct cell types in the mouse lateral hypothalamic area (LHA). In addition to 13 distinct non-neuronal cell populations, we define 15 distinct populations of glutamatergic and 15 distinct populations of GABAergic neurons, including both known and novel cell types. This comprehensive transcriptomic analysis of LHA cell types lays the groundwork for understanding the circuit-level underpinnings of LHA coordination of innate behavior.

2019-01-15 | GSE125065 | GEO

Histone Deacetylase 3 is an Epigenomic Brake in Macropahge Alternative Activation

Project description:This SuperSeries is composed of the following subset Series: GSE33596: Histone Deacetylase 3 is an Epigenomic Brake in Macrophage Alternative Activation (ChIP-Seq) GSE33608: Histone Deacetylase 3 is an Epigenomic Brake in Macrophage Alternative Activation (microarray) Refer to individual Series

2011-11-10 | E-GEOD-33609 | biostudies-arrayexpress

Diet induced obesity is independent of metabolic endotoxemia, Tlr4 signalling and hypothalamic inflammation

Project description:A number of studies have proposed that excess food intake, particularly of high fat diets arise due dysregulation of homeostatic mechanisms regulating neuroendocrine control of appetite and energy balance. Current dogma suggests high fat diets invoke hypothalamic inflammation which reduces hypothalamic sensitivity to metabolic and hormonal cues of conveying peripheral status of energy balance, such as leptin and insulin. A hypothesis for the mechanism leading to hypothalamic inflammation is based on high fat diet mediated changes in gut microbiota which are then proposed to increase circulating levels of lipopolysaccharide (LPS). This in turn activates a hypothalamic inflammatory response via the toll-like receptor (TLR4) and CD14. The aim of this study was to determine hypothalamic gene expression in response to long term feeding of a high fat diet, taking into account the importance of using a control diet with a similar composition and balanced for sucrose content.

2018-10-23 | E-MTAB-6929 | biostudies-arrayexpress