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NURR1 activation in skeletal muscle controls systemic energy homeostasis (RNA-seq)

ABSTRACT: NURR1 activation in skeletal muscle controls systemic energy homeostasis (RNA-seq)

PROVIDER: PRJNA541538 | ENA |

REPOSITORIES: ENA

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NURR1 activation in skeletal muscle controls systemic energy homeostasis

Project description:NURR1 activation in skeletal muscle controls systemic energy homeostasis

| PRJNA541534 | ENA

NURR1 activation in skeletal muscle controls systemic energy homeostasis (ChIP-seq)

Project description:NURR1 activation in skeletal muscle controls systemic energy homeostasis (ChIP-seq)

| PRJNA541537 | ENA

NURR1 activation in skeletal muscle controls systemic energy homeostasis (RNA-seq)

Project description:Skeletal muscle plays a central role in the control of metabolism and exercise tolerance. Analysis of muscle enhancers activated after exercise in mice revealed the orphan nuclear receptor NURR1/NR4A2 as a prominent component of exercise-responsive enhancers. We show that exercise enhances the expression of NURR1 and transgenic overexpression of NURR1 in skeletal muscle confers an endurance phenotype in mice. NURR1 expression in skeletal muscle is also sufficient to prevent hyperglycemia and hepatic steatosis by enhancing muscle glucose uptake and storage as glycogen. Furthermore, treatment of obese mice with putative NURR1 agonists increases energy expenditure, improves glucose tolerance, and confers a lean phenotype, mimicking the effects of exercise. These findings identify a key role for NURR1 in governance of skeletal muscle glucose metabolism and reveal a transcriptional link between exercise and metabolism. Our findings also identify NURR1 agonists as possible exercise mimetics with the potential to ameliorate obesity and other metabolic abnormalities.

2019-08-01 | GSE130838 | GEO

NURR1 activation in skeletal muscle controls systemic energy homeostasis (ChIP-seq)

2019-08-01 | GSE130839 | GEO

Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning

Project description:Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning

2023-10-24 | PXD046337 | iProX

NURR1 activation in skeletal muscle controls systemic energy homeostasis.

Project description: Not available

| S-EPMC6561277 | biostudies-literature

NURR1 activation in skeletal muscle controls systemic energy homeostasis

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-08-01 | GSE130840 | GEO

Cardiolipin Synthesis Governs Systemic Energy Homeostasis through Thermogenic Fat Mitochondria

Project description:Cardiolipin Synthesis Governs Systemic Energy Homeostasis through Thermogenic Fat Mitochondria

| PRJNA433399 | ENA

ER-associated degradation maintains postnatal muscle hypertophy and systemic energy metabolism

Project description:The growth of skeletal muscle relies on a delicate equilibrium between protein synthesis and degradation; however, how proteostasis is managed in the endoplasmic reticulum is largely unknown. Here, we report that the SEL1L-HRD1 endoplasmic reticulum (ER)-associated degradation (ERAD) complex, the primary molecular machinery that degrades misfolded proteins in the ER, is vital to maintain postnatal muscle growth and systemic energy balance. Myocyte-specific SEL1L deletion blunts the hypertrophic phase of muscle growth, resulting in a net zero gain of muscle mass during this developmental period and significant reduction in overall body growth. In addition, myocyte-specific SEL1L deletion triggered a systemic reprogramming of metabolism characterized by improved glucose sensitivity, enhanced beiging of adipocytes, and resistance to diet induced obesity. These effects were partially mediated by the upregulation of the myokine FGF21. These findings highlight the pivotal role of SEL1L-HRD1 ERAD activity in skeletal myocytes for postnatal muscle growth, and its physiological integration in maintaining whole-body energy balance.

2023-07-17 | GSE237194 | GEO

Cardiolipin Synthesis Governs Systemic Energy Homeostasis through Thermogenic Fat Mitochondria

Project description:Here we show that synthesis of the mitochondrial phospholipid cardiolipin is an indispensable driver of thermogenic fat function. Cardiolipin biosynthesis is robustly induced in brown and beige adipose upon cold exposure. Mimicking this response by overexpressing cardiolipin synthase (Crls1) enhances energy consumption in mouse and human adipocytes. Crls1 deficiency diminishes mitochondrial uncoupling in brown and beige adipocytes and elicits a nuclear transcriptional response through ER stress-mediated retrograde communication. Cardiolipin depletion in brown and beige fat abolishes adipose thermogenesis and glucose uptake and renders animals strikingly insulin resistant. We further identify a rare human CRLS1 variant associated with insulin resistance and show that adipose CRLS1 levels positively correlate with insulin sensitivity. Thus, adipose cardiolipin is a powerful regulator of organismal energy homeostasis through thermogenic fat bioenergetics.

2018-07-19 | GSE110297 | GEO

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