Genomics

Dataset Information

1

Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineage


ABSTRACT: Plasmacytoid dendritic cells develop from Ly6D+ lymphoid progenitors distinct from the myeloid lineage

PROVIDER: PRJNA542142 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR9035480_1.fastq.gz Fastqsanger.gz
SRR9035480_2.fastq.gz Fastqsanger.gz
SRR9035490_1.fastq.gz Fastqsanger.gz
SRR9035490_2.fastq.gz Fastqsanger.gz
SRR9035500_1.fastq.gz Fastqsanger.gz
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Publications


Dendritic cells (DC) are currently classified as conventional DCs (cDCs) and plasmacytoid DCs (pDCs). Through a combination of single-cell transcriptomic analysis, mass cytometry, in vivo fate mapping and in vitro clonal assays, here we show that, at the single-cell level, the priming of mouse hematopoietic progenitor cells toward the pDC lineage occurs at the common lymphoid progenitor stage, indicative of early divergence of the pDC and cDC lineages. We found the transcriptional signature of a  ...[more]

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