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Effect of cold atmospheric plasma (CAP) in MCF-7 breast cancer cells [dataset 1]

ABSTRACT: Effect of cold atmospheric plasma (CAP) in MCF-7 breast cancer cells [dataset 1]

PROVIDER: PRJNA543828 | ENA |

REPOSITORIES: ENA

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Effect of cold atmospheric plasma (CAP) in MCF-7 breast cancer cells [dataset 1]

Project description:Paclitaxel is a widely used therapeutic chemical for breast cancer treatment, however, cancer recurrence remains obstacle for improved prognosis of cancer patients. In the current study, cold atmospheric plasma (CAP) was examined for its potential use to overcome the drug resistance, which mainly comprised of reactive oxygen and nitrogen species. After developing a paclitaxel (Tx)-resistant MCF-7 (MCF-7/TxR) breast cancer cell, CAP was applied to the cells and its effect on recovery of drug sensitivity was examined in cellular as well as molecular aspect. The MCF-7/TxR cells restored sensitivity against Tx up to 70% by CAP. Comparison of genome-wide expression profiles between the Tx resistance cell and its CAP-treated cell identified 86 genes that commonly appeared with significant change. Notably, 48 genes including DAGLA and CEACAM1, which are known to contribute to the acquisition of Tx resistance, showed opposite expression in the two cellular status. The protein expression level of selected genes, DAGLA and CEACAM1, was recovered to that of their parental cell by CAP. Furthermore, the dysregulation of DAGLA and CEACAM1 in MCF-7/TxR alleviated the drug sensitivity recovery effect of CAP. Taken together, CAP inhibited the growth of Tx-resistant MCF-7 cancer cells and recovered Tx sensitivity by resetting expression of multiple drug resistance–related genes. These findings may contribute to extending the application of CAP to the treatment of Tx-resistant cancer.

2020-01-24 | GSE131477 | GEO

Effect of cold atmospheric plasma (CAP) in MCF-7 breast cancer cell [dataset 3]

2020-01-24 | GSE131479 | GEO

Effect of cold atmospheric plasma (CAP) on MCF-7 breast cancer cell (Illumina HumanHT-12 V4.0 beadchip)

Project description:genom-wide expression profiling of MCF-7, MCF-7 and CAP-treated MCF-7 cell. In result, cold atmospheric plasma different effect the CAP-treated MCF-7 breast cancer cell.

2019-07-26 | GSE110117 | GEO

Effect of cold atmospheric plasma (CAP) in MCF-7/TxR breast cancer cell [dataset 2]

2020-01-24 | GSE131478 | GEO

Effect of cold atmospheric plasma (CAP) on MCF-7 breast cancer cell (Agilent Human GE v3 8x60K Microarray)

Project description:Genom-wide expression profiling of MCF-7, MCF-7 and CAP-treated MCF-7 cell. In result, cold atmospheric plasma different effect the CAP-treated MCF-7 breast cancer cell.

2019-07-26 | GSE117491 | GEO

Effect of cold atmospheric plasma (CAP) in MCF-7

Project description:Effect of cold atmospheric plasma (CAP) in MCF-7

| PRJNA543822 | ENA

Effect of cold atmospheric plasma (CAP) in MCF-7 breast cancer cell [dataset 3]

Project description:Effect of cold atmospheric plasma (CAP) in MCF-7 breast cancer cell [dataset 3]

| PRJNA543830 | ENA

Cold atmospheric plasma reprograms the drug sensitivity of Tamoxifen-resistant MCF-7 breast cancer cell

Project description:genome-wide expression profiling of MCF-7, MCF-7/TamR and CAP-treated MCF-7/TamR cell. In result, cold atmospheric plasma re-sensitizes the Tamoxifen-resistant MCF-7 (MCF-7/TamR) breast cancer cell to the drug.

2017-07-12 | GSE95208 | GEO

Effect of cold atmospheric plasma (CAP) in MCF-7/TxR breast cancer cell [dataset 2]

Project description:Effect of cold atmospheric plasma (CAP) in MCF-7/TxR breast cancer cell [dataset 2]

| PRJNA543829 | ENA

ChIP-seq analysis reveals alteration of H3K4 trimethylation occupancy of cancer-related genes by cold atmospheric plasma

Project description:Cold atmospheric plasma (CAP) has obtained credits for cancer treatment by its ability to preferentially induce cancer cell death, while its molecular mechanism is under elucidation. Here, an epigenetic effect of CAP on cancer cell was examined by performing a genome-wide ChIP-seq for H3K4me3 in the MCF-7 breast cancer cell.

2019-07-26 | GSE117698 | GEO

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