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Single-cell RNA-seq of the intestine sample of ICR mice treated with busulfan and/or Alginate Oligosaccharides

ABSTRACT: Single-cell RNA-seq of the intestine sample of ICR mice treated with busulfan and/or Alginate Oligosaccharides

PROVIDER: PRJNA544244 | ENA |

REPOSITORIES: ENA

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Single-cell RNA-seq of the intestine sample of ICR mice treated with busulfan and/or Alginate Oligosaccharides

Project description:We profiled a single-cell RNA-seq on ICR mouse intestine treated with busulfan and or Alginate Oligosaccharides (AOS) from 3 weeks of age to 5 weeks of age (for 2 weeks) to study the rescue effect of AOS on the intestine development disrupted by busulfan. We collected single cell from intestine from the four groups AOS 0 (control), B+A 0 (busulfan alone), B+A 10 (busulfan plus AOS 10 mg/kg Body Weight). The the cells were further captured with 10x Genomics based single-cell system. By using single-cell RNA seq, we found busulfan damaged intestinal cells. AOS significantly improved the intestinal cell junction and microvilin formation. Besides, we provide candidate master regulons regulated by AOS. Our data here offers the opportunity for improving intestine under stress.

2020-04-29 | GSE131630 | GEO

Single-cell RNA-seq of the testis sample of ICR mice treated with busulfan and/or alginate oligosaccharides

Project description:We profiled a single-cell RNA-seq on ICR mouse testis treated with busulfan and or Alginate Oligosaccharides (AOS) from 3 weeks of age to 8 weeks of age (for 5 weeks) to study the rescue effect of AOS on the spermatogenesis disrupted by busulfan. We collected single cell from testis from the four groups AOS 0 (control), AOS 10 (AOS 10 mg/kg body weight (BW)), B+A 0 (busulfan alone), B+A 10 (busulfan plus AOS 10 mg/kg BW). The the cells were further captured with 10x Genomics based single-cell system. By using single-cell RNA seq, we found busulfan disrupted spermatogenesis by the dramatical decrease in germ cells. AOS significantly increased the number of germ cells and also promoted the germ cell development. Besides, we provide candidate master regulons regulated by AOS. Our data here offers the opportunity for treating of azoospermia or oligospermia.

2020-03-30 | GSE131629 | GEO

RNA-seq of mouse spleen samples from Alginate oligosaccharides and/or busulfan treatment groups

Project description:The goat of this project is to exploreAlginate oligosaccharides (AOS) effect on the recovery of spleen function. RNA-seq of spleen samples from different groups: Con, busulfan(B), AOS, B+AOS.

2021-12-01 | GSE143247 | GEO

RNA-seq of mouse lung samples from Alginate oligosaccharides and/or busulfan treatment groups

Project description:The goat of this project is to exploreAlginate oligosaccharides (AOS) effect on the recovery of lung function. RNA-seq of lung samples from different groups: Con, busulfan(B), AOS, B+AOS.

2021-12-01 | GSE143246 | GEO

RNA-seq of mouse liver samples from Alginate oligosaccharides and/or busulfan treatment groups

Project description:The goat of this project is to exploreAlginate oligosaccharides (AOS) effect on the recovery of liver function. RNA-seq of liver samples from different groups: Con, busulfan(B), AOS, B+AOS.

2021-12-01 | GSE143245 | GEO

RNA-seq of mouse kidney samples from Alginate oligosaccharides and/or busulfan treatment groups

Project description:The goat of this project is to exploreAlginate oligosaccharides (AOS) effect on the recovery of kidney function. RNA-seq of kidney samples from different groups: Con, busulfan(B), AOS, B+AOS.

2021-12-01 | GSE143243 | GEO

RNA-seq of mouse heart samples from Alginate oligosaccharides and/or busulfan treatment groups

Project description:The goat of this project is to exploreAlginate oligosaccharides (AOS) effect on the recovery of heart function. RNA-seq of heart samples from different groups: Con, busulfan(B), AOS, B+AOS.

2021-12-01 | GSE143242 | GEO

RNA-seq of the cultured testis sample of ICR mice treated with busulfan and/or Alginate Oligosaccharides (AOS)

Project description:RNA-seq of the cultured testis sample of ICR mice treated with busulfan and/or Alginate Oligosaccharides (AOS)

| PRJNA544801 | ENA

Single-cell RNA-seq of the testis sample of ICR mice treated with busulfan and/or alginate oligosaccharides

Project description:Single-cell RNA-seq of the testis sample of ICR mice treated with busulfan and/or alginate oligosaccharides

| PRJNA544236 | ENA

RNA-seq of mouse small intestine samples from different treatment groups

Project description:The aim of this project was to explore the role of Alginate oligosaccharides (AOS) on the development small intestine. The mice were treated with one dose busulfan then the mice were dosed with AOS for 5 weeks. Then the small intestine were collected. The RNA from small intestine was used for the RNA-seq analysis to search the role of AOS on small intestine development. Groups: W5A0 was from AOS 0 treatment; W5A10 was from AOS 10 treatment; W5BA0 was from busulfan and AOS 0 treatment; W5BA10 was from busulfan and AOS 10 treatment.

2020-09-30 | GSE137989 | GEO

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