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Massively parallel splicing reporter assay on designed sequence libraries


ABSTRACT: Massively parallel splicing reporter assay on designed sequence libraries

PROVIDER: PRJNA545827 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR9178590_1.fastq.gz Fastqsanger.gz
SRR9178590_2.fastq.gz Fastqsanger.gz
SRR9178591.fastq.gz Fastqsanger.gz
SRR9178586_1.fastq.gz Fastqsanger.gz
SRR9178586_2.fastq.gz Fastqsanger.gz
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Publications

Dissecting splicing decisions and cell-to-cell variability with designed sequence libraries.

Mikl Martin M   Hamburg Amit A   Pilpel Yitzhak Y   Segal Eran E  

Nature communications 20191008 1


Most human genes are alternatively spliced, allowing for a large expansion of the proteome. The multitude of regulatory inputs to splicing limits the potential to infer general principles from investigating native sequences. Here, we create a rationally designed library of >32,000 splicing events to dissect the complexity of splicing regulation through systematic sequence alterations. Measuring RNA and protein splice isoforms allows us to investigate both cause and effect of splicing decisions,  ...[more]

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