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Genomic instability induced by chronic exposure of furfural in yeast

ABSTRACT: Genomic instability induced by chronic exposure of furfural in yeast

PROVIDER: PRJNA545992 | ENA |

REPOSITORIES: ENA

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Genomic instability induced by chronic exposure of furfural in yeast

Project description:Furfural is a potential mutagenic agent. To explore the global effect of furfural on genomic intergrity, chromosomal alterations in 14 furfural-treated isolates of JSC25-1 strain were determined by whole genome SNP microarrays at a resolution about 1kb. Our results showed furfural exposure results in striking elevations of both mitotic recombination and aneuploidy events in yeast.

2019-06-04 | GSE132128 | GEO

Genomic instability induced by furfural-treated in S. cerevisiae [whole genome]

Project description:Furfural is a key inhibitor in S. cerevisiae fermentation causing serious economic loss. To understand the toxic mechanisms of furfural-induced genomic instability and phenotypic evolution, we mapped chromosomal alterations in 21 furfural-treated yeast strains by whole genome SNP microarrays at a resolution about 1kb.

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Genomic instability induced by furfural-treated in S. cerevisiae

Project description:Genomic instability induced by furfural-treated in S. cerevisiae

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Exposure of non-lethal doses of furfural drives genomic alterations and phenotypic evolution in Saccharomyces cerevisiae

Project description:Using multiple genetic screening assays and high-throughput analysis approaches, this study explored the genotoxic and evolutional effects of nonlethal dosages of furfural in yeast model.

2022-08-01 | GSE210078 | GEO

Carbendazim induced genomic instability in yeast

Project description:Carbendazim induced genomic instability in yeast

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Genomic instability induced by furfural-treated in S. cerevisiae [whole genome]

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Genomic instability induced by furfural-treated in S. cerevisiae [sectored colonies]

Project description:Genomic instability induced by furfural-treated in S. cerevisiae [sectored colonies]

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Genomic instability induced by furfural-treated in S. cerevisiae [sectored colonies]

Project description:Furfural is a key inhibitor in S. cerevisiae fermentation causing serious economic loss. To disclose of the recombinational DNA lesions induced by furfural, we analyzed 19 JSC25-derived sectored colonies using chromosome IV SNP-specific microarrays. The parent diploid S. cerevisiae strain JSC25 (constructed by crossing two haploid strains isogenic W303-1A and YJM789) was homologous for ade2-1 alleles. One copy of gene SUP4-o, an ochre-suppressing tRNA, was inserted at the end of right arm of chromosome IV. Under normal conditions, the colony color of JSC25 is pink. A crossover event occurred on the right arm of chromosome IV at the first cell cycle would result in a white/red sectored colony on solid plate.

2017-10-13 | GSE104880 | GEO

Carbendazim induced genomic instability in yeast

Project description:Carbendazim (Methyl benzimidazol-2-ylcarbamate; MBC) is an antimitotic drug used for broad-spectrum fungicide, antineoplastic and mutagen in microbial breeding. Using a customized SNP microarray technology, this work revealed the effect of MBC on genomic instability (loss of heterozygosity, chromosomal rearrangements and aneuploidy) in the diploid yeast Saccharomyces cerevisiae JSC25.

2018-03-21 | GSE112062 | GEO

Heat shock stimulates genomic instability and phenotypic variations in yeast

Project description:Yeast Saccharomyces cerevisiae has been widely used as a model system for studying genomic instability. In this study, heat-shock-induced genomic alterations were explored in the heterozygous diploid yeast strain JSC25-1. In combination of the whole-genome microarray, the patterns of chromosomal instability induced by heat shock could also be explored at a whole genome level. Using this system, we found heat-shock treatment resulted in hundreds-fold higher rate of genomic alterations, including aneuploidy and loss of heterozygosity (LOH).

2020-05-18 | GSE150711 | GEO

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