Genomics

Dataset Information

1

Single cell RNA sequencing of colorectal cancer with diverse tissue dissociation protocols or fresh vs. frozen cell preparations.


ABSTRACT: Single cell RNA sequencing of colorectal cancer with diverse tissue dissociation protocols or fresh vs. frozen cell preparations.

PROVIDER: PRJNA546616 | ENA |

REPOSITORIES: ENA

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Publications

Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer.

Lee Hae-Ock HO   Hong Yourae Y   Etlioglu Hakki Emre HE   Cho Yong Beom YB   Pomella Valentina V   Van den Bosch Ben B   Vanhecke Jasper J   Verbandt Sara S   Hong Hyekyung H   Min Jae-Woong JW   Kim Nayoung N   Eum Hye Hyeon HH   Qian Junbin J   Qian Junbin J   Boeckx Bram B   Lambrechts Diether D   Tsantoulis Petros P   De Hertogh Gert G   Chung Woosung W   Lee Taeseob T   An Minae M   Shin Hyun-Tae HT   Joung Je-Gun JG   Jung Min-Hyeok MH   Ko Gunhwan G   Wirapati Pratyaksha P   Kim Seok Hyung SH   Kim Hee Cheol HC   Yun Seong Hyeon SH   Tan Iain Bee Huat IBH   Ranjan Bobby B   Lee Woo Yong WY   Kim Tae-You TY   Choi Jung Kyoon JK   Kim Young-Joon YJ   Prabhakar Shyam S   Tejpar Sabine S   Park Woong-Yang WY  

Nature genetics 20200525 6


Immunotherapy for metastatic colorectal cancer is effective only for mismatch repair-deficient tumors with high microsatellite instability that demonstrate immune infiltration, suggesting that tumor cells can determine their immune microenvironment. To understand this cross-talk, we analyzed the transcriptome of 91,103 unsorted single cells from 23 Korean and 6 Belgian patients. Cancer cells displayed transcriptional features reminiscent of normal differentiation programs, and genetic alteration  ...[more]

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