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Small intestinal inflammation shapes the transcriptomic signature of incoming monocytes in a partially Trem1-dependent mechanism

ABSTRACT: Small intestinal inflammation shapes the transcriptomic signature of incoming monocytes in a partially Trem1-dependent mechanism

PROVIDER: PRJNA548348 | ENA |

REPOSITORIES: ENA

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Small intestinal inflammation shapes the transcriptomic signature of incoming monocytes in a partially Trem1-dependent mechanism

Project description:In this study we showed that Trem1 is one of genes that were differentially regulated in donor monocytes recovered from non-inflamed and inflamed small intestine of recipient mice. We, therefore, aimed at investigating the role of Trem1 on regulating the monocyte adapatation and differentiation in a context-dependent manner. Thus, the gene expression of WT and Trem1-deficient donor monocytes that are recruited to non-inflamed and inflamed small intestine one day after transfer.

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