Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression changes in mouse breast cancer cells (4T1) after axitinib resistance

ABSTRACT: Gene expression changes in mouse breast cancer cells (4T1) after axitinib resistance

PROVIDER: PRJNA548373 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Gene expression changes in mouse breast cancer cells (4T1) after axitinib resistance

Project description:RNA sequencing analysis was used to identify changes in mouse breast cancer cells (4T1) resistant to axitinib (AxR).

2019-06-12 | GSE132568 | GEO

Identification of a Highly Immunogenic Mouse Breast Cancer Sub Cell Line, 4T1-S

Project description:Recently, cancer immunotherapy has been paid much attention because of its improved efficacy and low frequency of adverse effects. A mouse breast cancer cell line, 4T1, has been known as poorly immunogeneic and highly metastatic cell line. In this study, we have identified a sub cell line of 4T1, designated as 4T1-Sapporo (4T1-S), which could induce a strong immune response against the same line. When 4T1-S was subcutaneously injected, striking enlargement of draining lymph nodes and increase of activated T cells were observed. The strong immune responses could not be observed when 4T1-S was injected to nude mice, indicating that this phenomenon is mediated by T cell response. Identification of 4T1-S characteristics may help to improve immunotherapy against breast cancer. 4T1-A1, 4T1-A2, 4T1-S1, 4T1-S2

2015-11-01 | E-GEOD-71926 | biostudies-arrayexpress

Glycogene expression changes between different passages in the 4T1 Mouse metastatic breast cancer cell line

Project description:This laboratory's focus is on the immune response to carbohydrate antigens, with an emphasis on modalities to analyze and to increase the immune response. We are also interested in carbohydrate drug targeting. The hypothesis is that these 2 variants have different cell surface carbohydrate expression, which results in different adhesion patterns, which ultimately results in different metastasis patterns. Evidence for expression differences and loss of the variants ability to metastasize to the lung could have clinical implications in the prevention of metastasis to different organs. The 4T1 mouse metastatic breast cancer cell line is known to change with passages in culture. Our data has shown changes cause the cells to metastasize to the intestine rather than to the lung. Four classes of RNA were analyzed: one each from 4T1 metastatic cell line variant #1, 4T1 variant #2, non-metastatic cell lines 4T07, and non-metastatic cell line 67NR. Classes were prepared in triplicate for a total of 12 samples. All samples were hybridized to the custom designed CFG GLYCOv2 glycogene array.

2011-02-17 | E-GEOD-27354 | biostudies-arrayexpress

Expression data from adult mice breast cancer cell 4T1

Project description:Microaaray data for CD44v8-10-positive / CD44v8-10-negative 4T1 cancer cells (mouse breast cancer cells) We used microarrays to detail the global programming of gene expression of 4T1 cells depending on whether CD44v is present or not. 4T1 cells, one of the mouse breast cancer cells, were selected for RNA extraction and hybridization on Affymetrix microarrays. We sought to obtain the data about to which extent gene expression profile is different between CD44v-positive and CD44v-negative 4T1 cancer cells.

2012-02-15 | E-GEOD-35803 | biostudies-arrayexpress

Identification of a Highly Immunogenic Mouse Breast Cancer Sub Cell Line, 4T1-S

2015-11-01 | GSE71926 | GEO

Expression data from 4T1 parental breast cancer cell line and 4T1-3R liver metastatic cells (4T1-3R_L).

Project description:We used 4T1 murine breast cancer cells to establish a syngeneic tumor model and found that liver metastatic cells exhibited serveral biological and molecular characteristic that are distinct from parental 4T1 cells. We used microarrays to analyze 4T1-3R_L cells exhibited several CSC related genes compared to 4T1 cells.

2022-07-29 | GSE181102 | GEO

Effect of TGFb1 treatment and WISP1 overexpression on 4T1 breast cancer cells

Project description:This study set out to identify TGFb1 transcriptional targets in breast cancer cells. 4T1 breast cancer cells were treated with TGFb1 for 24h and transcripts that were significantly regulated were identified. Wisp1 was identified as one of the genes most highly upregulated by TGFb1. To identify the transcriptional targets of Wisp1, 4T1 cells were then virally transduced to increase Wisp1 expression. The gene expression profiles of Wisp1-overexpressing 4T1 cells were determined and revealed that Wisp1 overexpression does not result in major gene expression changes in 4T1 cells.

2019-07-08 | GSE110912 | GEO

Differential expression profile of 4T1 Breast Cancer Mouse Model

Project description:This study aimed to investigate the protective mechanisms of DMDD liposome on breast cancer, BALB/c mice were transplanted subcutaneously with 4T1 cells into the right axilla for 1 weeks, followed by various medicines for 2 weeks. The transcriptomic analysis was performed in liver tissues by RNA-seq.

2021-11-25 | GSE189411 | GEO

Expression data from adult mice breast cancer cell 4T1

2012-02-15 | GSE35803 | GEO

Differential expression profile of 4T1 Breast Cancer Mouse Model

Project description:Differential expression profile of 4T1 Breast Cancer Mouse Model

| PRJNA782963 | ENA