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Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in esophageal adenocarcinoma [4C-Seq]

ABSTRACT: Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in esophageal adenocarcinoma [4C-Seq]

PROVIDER: PRJNA548758 | ENA |

REPOSITORIES: ENA

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Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in esophageal adenocarcinoma

Project description:Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in esophageal adenocarcinoma

| PRJNA549160 | ENA

Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in esophageal adenocarcinoma

Project description:Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in esophageal adenocarcinoma

| PRJNA548754 | ENA

Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in esophageal adenocarcinoma [ChIP-Seq]

Project description:Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in esophageal adenocarcinoma [ChIP-Seq]

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Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in esophageal adenocarcinoma [ChIP-Seq]

Project description:We profiled fresh-frozen esophageal tumor and normal samples and cell lines with chromatin immunoprecipitation sequencing (ChIP-Seq). Mathematically modeling was performed to establish (super)-enhancers landscapes and inter-connected transcriptional circuitry formed by master TFs. Coregulation and cooperation between master TFs was investigated by ChIP-Seq, RNASeq, 4C-Seq and luciferase assay. Biological functions of candidate factors were evaluated by measuring cell proliferation, colony formation, cell apoptosis and xenograft growth.

2019-07-30 | GSE132680 | GEO

Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in esophageal adenocarcinoma [4C-Seq]

Project description:We report the application of circular chromatin conformation capture (4C) sequencing technology for master transcription factor (KLF5 and ELF3) in human esophageal adenocarcinoma cancer cell lines (ESO26) . By baiting the promoters of KLF5 and ELF3, we esatblished the interaction with unknown enhnacer marks.

2019-07-30 | GSE132685 | GEO

Master transcription factors form interconnected circuitry and orchestrate transcriptional networks in esophageal adenocarcinoma

Project description:This SuperSeries is composed of the SubSeries listed below.

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Chromatin immunoprecipitation analysis of human hepatocyte regulatory circuitry

Project description:We mapped the transcriptional regulatory circuitry for six master regulators in human hepatocytes using chromatin immunoprecipitation and high-resolution promoter microarrays. The results show that these regulators form a highly interconnected core circuitry, and reveal the local regulatory network motifs created by regulator-gene interactions. Auto-regulation was a prominent theme among these regulators. We found that hepatocyte master regulators tend to bind promoter regions combinatorially and that the number of transcription factors bound to a promoter corresponds with observed gene expression. Our studies reveal portions of the core circuitry of human hepatocytes.

2006-05-09 | E-WMIT-9 | biostudies-arrayexpress

Distal regulation mediated Core Transcriptional Regulatory Circuitry in Esophageal Squamous Cell Carcinoma

Project description:In esophageal squamous cell carcinoma (ESCC), the core regulatory circuitry is ill-defined and the limited clinical approaches are available currently for the treatment of ESCC. Here, using enhancer profiling and CRC programme, we generated ESCC-dependent epigenomic-transcriptional regulatory circuitry, elaborated the exquisite work model mediated by core TFs and SEs through physical interaction between enhancers and promoter, and identified the crucial target of ESCC regulatory network.

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Distal regulation mediated Core Transcriptional Regulatory Circuitry in Esophageal Squamous Cell Carcinoma [RNA-seq]

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Distal regulation mediated Core Transcriptional Regulatory Circuitry in Esophageal Squamous Cell Carcinoma [ChIP-seq]

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