Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single cell sequencing of Angiotensin II-infused mouse left ventricle

ABSTRACT: Single cell sequencing of Angiotensin II-infused mouse left ventricle

PROVIDER: PRJNA549697 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Single cell sequencing of Angiotensin II-infused mouse left ventricle

Project description:Single cell RNA-seq of heart left ventricle a wild type mouse after 28 days of angiotensin II treatment

2019-07-08 | GSE133015 | GEO

Gene expression profiling in left cardiac ventricles of C57Bl/6J and C57Bl/6N male mice treated for 48 h with angiotensin II 500 ng/kg/min.

Project description:Analysis of angiotensin II effect on left ventricle at gene expression level. The hypothesis tested in the present study was that angiotensin II treatment may affect gene expression in left ventricle in a strain specific manner. Results provide important information about which genes respond to angiotensin II in C57Bl/6N male mice compared to their C57Bl/6J counterparts. Total RNA obtained from isolated left ventricles from C57Bl/6J and C57Bl/6N mice subjected to 48 hours of angiotensin II infusion, via osmotic mini-pumps (500ng/kg/h) implanted sub-cutaneously, compared to sham operated controls.

2014-12-12 | E-GEOD-53269 | biostudies-arrayexpress

Gene expression profiling in left cardiac ventricles of C57Bl/6J and C57Bl/6N male mice treated for 48 h with angiotensin II 500 ng/kg/min.

2014-12-12 | GSE53269 | GEO

miRNA expression profiling in mesenteric arteries of mice infused or not with angiotensin II for 7 and 14 days

Project description:We use next-generation sequencing (NGS) to profile miRNA in small arteries of mice infused with angiotensin (Ang) II for 7 and 14 days. The goal is to identify differentially expressed miRNAs that are associated with Ang II-induced vascular injury and hypertension.

2019-05-22 | GSE101704 | GEO

Gene expression regulation by angiotensin II in late gestation fetal sheep

Project description:We undertook a transcriptome-wide discovery approach to provide information on the involved gene regulatory responses to change in fetal cardiac mass in response to chronic infusion of angiotensin II or losartan. One of each of 8 twin fetus pairs was infused with either angiotensin II or losartan daily for five days in utero. A portion of the left ventricular free wall of treatment and control fetuses was excised, homogenized in a reagent, and then total RNA was then isolated and assayed on the agilent microarray

2013-08-09 | E-GEOD-45463 | biostudies-arrayexpress

Total RNA expression profiling in mesenteric arteries of mice infused or not with angiotensin II for 7 and 14 days

Project description:We used next-generation sequencing (NGS) to profile total RNA in small arteries of mice infused or not with angiotensin (Ang) II for 7 and 14 days. The goal was to identify differentially expressed genes that are associated with Ang II-induced vascular injury and hypertension.

2019-05-22 | GSE101707 | GEO

Adult rabbit left ventricle RNAseq

Project description:Adult rabbit left ventricle RNAseq

| PRJNA475561 | ENA

Angiotensin II induced aneurysms in male ApoE mice

Project description:In this study we used microarrays to examine relative genes expression within the aorta of ApoE-/- infused with angiotensin II in relation to aneurysm formation. Infusion of angiotensin II induces aortic dilatation particularly of the suprarenal aorta in ApoE-/- mice. Based on studies carried out in our and other laboratories the response to angiotensin II is variable, with some mice developing large aneurysms but other animals appearing resistant to aneurysm formation with aortic diameters similar to that of saline controls. We compared RNA expression from whole aortas of 17 week old male ApoE-/- mice exposed to angiotensin II (1.44 Âµg/kg/min) for 4 weeks where there was clear evidence of aortic aneurysm formation (n=5) with that of mice failing to develop aneurysms (n=7) and those exposed to saline infusion (n=6). AAA was defined as diameter of suprarenal aorta greated than 1.5mm measured on photographs of aortas at necroscopy. Keywords: Disease state analysis 18 samples analysed, AAA (n=5), no AAA (n=7), saline (n=6). AAA - abdominal aortic aneurysm

2010-06-24 | E-GEOD-12591 | biostudies-arrayexpress

Angiotensin II induced aneurysms in male ApoE mice

Project description:In this study we used microarrays to examine relative genes expression within the aorta of ApoE-/- infused with angiotensin II in relation to aneurysm formation. Infusion of angiotensin II induces aortic dilatation particularly of the suprarenal aorta in ApoE-/- mice. Based on studies carried out in our and other laboratories the response to angiotensin II is variable, with some mice developing large aneurysms but other animals appearing resistant to aneurysm formation with aortic diameters similar to that of saline controls. We compared RNA expression from whole aortas of 17 week old male ApoE-/- mice exposed to angiotensin II (1.44 µg/kg/min) for 4 weeks where there was clear evidence of aortic aneurysm formation (n=5) with that of mice failing to develop aneurysms (n=7) and those exposed to saline infusion (n=6). AAA was defined as diameter of suprarenal aorta greated than 1.5mm measured on photographs of aortas at necroscopy. Keywords: Disease state analysis

2009-08-26 | GSE12591 | GEO

RNA-seq of heart left ventricle

Project description:RNA-seq of heart left ventricle

| PRJNA549694 | ENA