Project description:We compared a large panel of human glioblastoma stem-like (GS) cell lines, corresponding primary tumors and conventional glioma cell lines to identify cell lines that preserve the transcriptome of human glioblastomas most closely, thereby allowing identification of shared therapeutic targets. We used Affymetrix HG-U133 Plus 2.0 microarrays to compare human glioblastoma stem-like (GS) cell lines, corresponding primary tumors and conventional glioma cell lines. We extracted total RNA from 32 conventional glioma cell lines, 12 GS cell lines (8 in two different passages), 7 clonal sublines derived from two GS lines, 12 original tumors, and 4 monolayer cultures established from the same tumors as GS-lines using standard serum conditions.

2011-02-12 | E-GEOD-23806 | biostudies-arrayexpress

Gene expression of primary Glioblastoma cell lines

Project description:We investigated the gene expression profiles of primary Human GBM cell lines. To represent the complexity of the GBM tissues, we uesd cell lines belonging to two different subtypes (HuTu10, proneural; HuTu13, Mesenchymal).

2020-10-02 | GSE133470 | GEO

SNP Analysis of Primary Glioblastoma Cell Lines

Project description:Genomic abnormalities that are associated with mesecnhmal phenotype of GBM were detected in glioblastoma cell lines. Keywords: SNP array analysis of glioblastome cell lines.

2006-06-16 | GSE5082 | GEO

Genotyping of human primary glioblastoma cell lines

Project description:Genomic abnormalities that are associated with mesecnhmal phenotype of GBM were detected in glioblastoma cell lines. Experiment Overall Design: Whole genomic DNA of GBM cell lines (W-98, D431, F-502, and S-496) and the fibroblast cell line were evaluated for allelic imbalances and chromosomal copy number abnormalities by using a highdensity single-nucleotide polymorphic (SNP) array analysis (Affymetrix XbaI 131 Array).

2008-06-13 | E-GEOD-5082 | biostudies-arrayexpress

Expression data from glioblastoma derived sphere lines, adherent cell lines and their original glioblastoma tumor

Project description:Expression data from glioblastoma derived sphere lines, adherent cell lines and their original glioblastoma tumor

| PRJNA412249 | ENA

Expression data from patient-derived primary glioblastoma cell lines

Project description:Genetic alterations that give rise to tumorigenesis result in altered epigenetic and gene expression profiles. We sought to identify and better understand potential consequences of MTAP deletion in glioblastoma by examining gene expression profiles of MTAP deleted and MTAP WT GBM cell lines. MTAP deletion results in accumulation of the abberant metabolite, MTA, with potential consequences to epigenetic regulation and signal transduction. We also examined the cellular response (gene expression) to purine deprivation with L-Alanosine treamment

2020-05-12 | GSE114867 | GEO

Expression data from glioblastoma derived sphere lines, adherent cell lines and their original glioblastoma tumor

Project description:Glioblastoma (GBM) derived sphere lines and adherent cell lines are an important tool for research in basic and translational neuro-oncology. Documentation of their genetic identity has become a requirement for scientific journals and grant applications to exclude cross-contamination and misidentification that lead to misinterpretation of results. Here, we report expression data for 26 samples including 4 GBM derived sphere lines (4 x 3 replicates), 2 GBM derived sphere lines passaged through intracranial transplantation (2x 1), 2 adherent GBM derived cell lines (2 + 2 x 3 replicates), 4 corresponding glioblastoma tumors and 2 non-tumor brain tissues.

2017-09-27 | GSE104291 | GEO

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