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Transcriptome profiling of differentiating mESCs upon treatment with Crataegus extract WS®1442 and its subfraction MeOH eluate

ABSTRACT: Transcriptome profiling of differentiating mESCs upon treatment with Crataegus extract WS®1442 and its subfraction MeOH eluate

PROVIDER: PRJNA551956 | ENA |

REPOSITORIES: ENA

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Transcriptome profiling of differentiating mESCs upon treatment with Crataegus extract WS®1442 and its subfraction MeOH eluate

Project description:In order to get mechanistic insights into the cardiomyogenic and differentiation-promoting activity of Crataegus spp. Extract WS®1442 and the identified bioactive subfractions (MeOH eluate), we have employed whole genome microarray expression profiling after 6 hours and 24 hours of treatment. We found that stress-associated genes are affected as well as specific signaling pathways such as TGFbeta, FGF, BDNF and retinoic acid.

2019-11-07 | GSE133572 | GEO