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Transcriptomic analysis of the soleus muscle extracted from Dnm2 K562E point-mutant heterozygous mice

ABSTRACT: Transcriptomic analysis of the soleus muscle extracted from Dnm2 K562E point-mutant heterozygous mice

PROVIDER: PRJNA555329 | ENA |

REPOSITORIES: ENA

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Transcriptomic analysis of the soleus muscle extracted from Dnm2 K562E point-mutant heterozygous mice

Project description:RNA sequencing was performed to evaluate the impact of Dnm2 K562E mutation in the soleus muscle. The assessment of the dataset reveals a large number of differentially regulated transcripts between animals of both genotypes. This is consistent with a dominant phenotype caused by the Dnm2 K562E point mutation on the muscle.

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Genetic downregulation of Dnm2 as a therapeutic approach in a murine model of X-linked myotubular myopathy (Mtm1-/y)

Project description:In this study, we performed RNA sequencing on tibialis anterior muscle of male mice. WT and Mtm1 deficient (Mtm1-/y) mice as well as on Dnm2+/- mice and on Mtm1-/y mice crossed with Dnm2+/- (Mtm1-/yDnm2+/-) were sequenced. A longitudinal follow up was established by sequencing all the genotypes at E18.5, 2w and 7w.

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Transcription profiling by array of mouse P6 retinal endothelial cells extracted from wildtype and dll4 heterozygous mice

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Transcription profiling of rat soleus during chronic intermittent physical inactivity

Project description:Global gene expression of the rat soleus muscle was assessed with microarrays after 11 days of intermittent physical inactivity (10 hr/day) and compared to normally caged rats with voluntary standing and intermittent cage movements. Experiment Overall Design: Rats were prevented from standing on the their hindlimbs for 10 hrs/day for 11 days and compared to caged rats with normal standing/ambulatory activity. RNA was extracted from soleus muscles and each array represents the pooling of the RNA from the soleus of 4-5 different rats.

2008-06-13 | E-GEOD-5217 | biostudies-arrayexpress

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