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Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells (ATAC-seq)

ABSTRACT: Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells (ATAC-seq)

PROVIDER: PRJNA556432 | ENA |

REPOSITORIES: ENA

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Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells

Project description:Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells

| PRJNA556429 | ENA

Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells (BLISS)

Project description:Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells (BLISS)

| PRJNA556433 | ENA

Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells (RNA-seq)

Project description:Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells (RNA-seq)

| PRJNA556431 | ENA

Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells [BLISS human]

Project description:Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells [BLISS human]

| PRJNA630892 | ENA

Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells [BLISS human]

Project description:The number and position of breaks using BLISS-seq was measured in MCF-7 cells upon irradiation with 10 Gy and with or without the use of the antioxidant (N-acetylcysteine, NAC, 10mM).

2020-07-07 | GSE150016 | GEO

Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells (BLISS)

Project description:The depletion of HMGB1 reduces the deposition of histones on naked DNA (Celona et al, 2011). in primary MEFs and yeast. We verified that the downmodulation of HMGB1 decreases histone level also in a model of murine mesothelioma. HMGB1 was KD in Murine Mesothelioma AB22 cells by the expression of a shRNA. Nucleosome positioning and occupancy were tested by ATAC-seq. Since a reduced amount of nucleosomes increase the cell sensitivity to gamma irradiatio, we tested the number and position of breaks using BLISS-seq.

2020-07-07 | GSE134797 | GEO

Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells (ATAC-seq)

2020-07-07 | GSE134796 | GEO

Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells (RNA-seq)

2020-07-07 | GSE134795 | GEO

Nucleosomes protect DNA from irradiation-induced double strand breaks in living cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-07-07 | GSE134798 | GEO

Doxorubicin induces double-strand breaks at CpG island promoters

Project description:Doxorubicin is a widely used chemotherapeutic drug that intercalates between DNA base-pairs and posions Topoisomerase II, although the mechanistic basis for cell killing remains speculative. Here we show that both anthracyclines and Topoisomerase II poison cause enhanced DNA double-strand breaks around CpG island promoters of active genes genome-wide. We propose that torsion-based enhancement of nucleosome turnover exposes promoter DNA, ultimately causing DNA breaks around promoters that contributes to cell killing. We have analyzed mouse squamous cell carcinoma cells treated with doxorubicin, aclarubicin and etoposide. The direct in situ Breaks Labeling, Enrichment on Streptavidin (BLESS, PMID 23503052) method was used for mapping DNA double-strand breaks genome-wide.

2015-01-31 | E-GEOD-62927 | biostudies-arrayexpress

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