Project description:Here we use an improved single-cell chromatin profiling approach to determine epigenomic alterations across tumor progression in a mouse model of lung adenocarcinoma (LUAD). Specifically, we induced tumors by providing Adeno-SPC-Cre virus to mice intratracheally to induce tumors due to conditional expression the Kras G12D mutation and loss of p53 (termed the KPT model). Mice also expressed a tdTomato reporter allele allowing for the sorting of tumor cells in late-stages of tumor progression. Using a combinatorial indexing approach (sciATAC-seq), we identify an epigenomic continuum representing a loss of cellular identity and progression towards a metastatic state.

2020-07-23 | GSE134812 | GEO

Single-cell epigenomics identifies a premetastatic regulatory program in lung adenocarcinoma [scATAC-seq]

2020-07-23 | GSE145192 | GEO

Single-cell epigenomics identifies a premetastatic regulatory program in lung adenocarcinoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-07-23 | GSE145194 | GEO

eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

Project description:eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

| PRJNA515945 | ENA

Characterizing an HSF1-dependent transcriptional program in metastatic lung adenocarcinoma

Project description:Characterizing an HSF1-dependent transcriptional program in metastatic lung adenocarcinoma

| PRJNA627725 | ENA