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MiRNAs expression in murine liver during Schistosoma japonicum infection

ABSTRACT: miRNAs expression in murine liver during Schistosoma japonicum infection

PROVIDER: PRJNA556656 | ENA |

REPOSITORIES: ENA

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miRNAs expression in murine liver during Schistosoma japonicum infection

Project description:It is well recognized that parasitic helminth infections, which afflict more than one billion people globally, correlate with a decreased prevalence of metabolic diseases, including obesity and type 2 diabetes, but the molecular mechanisms involved remain to be determined. Using microarrays, we quantified the temporal gene expression profiles in the liver of Schistosoma japonicum-infected C57BL/6 mice at 9 weeks post infection with that from uninfected mice as controls. More than 150 miRNAs were differentially expressed in the liver during S. japonicum infection, and miRNA-mRNA network would provide new evidence for the negtive correlation between S. japonicum infection and metabolism.

2019-07-26 | GSE134866 | GEO

Mice liver RNA-Seq during Schistosoma japonicum infection

Project description:The gogal of this study is to use RNA-Seq to systematically investigate the dynamics of the liver transcriptome over Schistosoma japonicum infection.

2020-10-15 | GSE101656 | GEO

Microtus fortis liver RNA-Seq during Schistosoma japonicum infection

Project description:The gogal of this study is to use RNA-Seq to systematically investigate the dynamics of the liver transcriptome over Schistosoma japonicum infection.

2020-10-15 | GSE101654 | GEO

MicroRNA-gene expression network in murine liver during Schistosoma japonicum infection

Project description:Schistosomiasis japonica remains a significant public health problem in China and Southeast Asian countries. The most typical and serious outcome of the chronic oriental schistosomiasis is the progressive granuloma and fibrosis in the host liver, which has been a major medical challenge. However, the molecular mechanisms that underlie the hepatic pathogenesis induced by schistosomal egg deposition have not yet been well-defined. Using microarrays, we quantified the temporal gene expression profiles in the liver of Schistosoma japonicum-infected BALB/c mice at day 15, 30, and 45 post infection (pi) with that from uninfected mice as controls. Meanwhile, microRNA expression profiles from the same samples were decoded by parallel solexa sequencing. Gene expression alternation associated with liver damage was observed even at early stage of infection (e.g., pi 15), which became more magnificent onset of egg deposition within the liver tissue. Up-regulated genes were dominantly associated with inflammatory infiltration of liver during S. japonicum infection, whereas down-regulated genes primarily led to the hepatic functional disorders. More than 130 miRNAs were differentially expressed during S. japonicum infection, and dynamic miRNA-gene co-expression network has been constructed during the development of hepatic pathology.

2013-06-12 | GSE45985 | GEO

MicroRNA-gene expression network in murine liver during Schistosoma japonicum infection

2013-06-12 | E-GEOD-45985 | biostudies-arrayexpress

Altered levels of circulating miRNAs are associated with Schistosoma japonicum infection in mice

Project description:miRNA profiling of S. japonicum infected mouse plasma comparing control untreated mouse plasma. Schistosomiasis, caused by dioecious flatworms in the genus Schistosoma, is torturing people predominantly in the developing countries. Knowledge on schistosome-host interaction and its parasitism may result in the development of novel strategies for schistosomiasis control. MicroRNAs (miRNAs) are involved in a wide range of biological processes including development, cell proliferation, metabolism ,signal transduction, et al. Circulating miRNAs are not only important biomarker associated the process of pathogenesis in many diseases and also are able to regulate target gene expression in recipient cells, just like hormones. In the present study, we investigated circulating miRNA profile associated with S. japonicum infection in mice using miRNA microarray.

2015-09-30 | GSE63135 | GEO

MicroRNAs are involved in the regulation of ovary development in the pathogenic blood fluke Schistosoma japonicum

Project description:We report on the small RNA profiles of Schistosoma japonicum (S. japonicum) miRNAs using small RNA deep sequencing in the key stages of male-female pairing, gametogenesis, and egg production. Examination of different miRNAs between males and females in Schistosoma japonicum

2016-01-07 | E-GEOD-74654 | biostudies-arrayexpress

Schistosoma japonicum

Project description:Schistosoma japonicum

| PRJNA29491 | ENA

MicroRNAs are involved in the regulation of ovary development in the pathogenic blood fluke Schistosoma japonicum

2016-01-07 | GSE74654 | GEO

Longitudinal Immune Profiling Highlights CD4+ T cell Exhaustion Correlated with Liver Fibrosis in Schistosoma japonicum Infection

Project description:Schistosoma japonicum causes severe disease or even death and liver fibrosis is the major damage, which is caused by immunopathological injury. However, a comprehensive understanding of the immune cell changes during S. japonicum infection is lacking. Here, we performed single-cell RNA-sequencing and T/B cell receptor sequencing (scRNA-seq/scTCR-seq/scBCR-seq) of the total mouse splenocytes after cercaria infection.The changes of immune cells with advancing disease stages were analyzed and the relationship with liver fibrosis was investigated.

2022-11-01 | GSE193216 | GEO

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