Project description:Strain Parabacteroides distasonis TSDC16.1-1.3 (species Parabacteroides distasonis) was isolated from the fecal microbiota of a USA female at time point zero . The species name was assigned by genome clustering.

| PRJEB3646 | ENA

Parabacteroides distasonis TSDC16.1-1.2

Project description:Strain Parabacteroides distasonis TSDC16.1-1.2 (species Parabacteroides distasonis) was isolated from the fecal microbiota of a USA female at time point zero . The species name was assigned by genome clustering.

| PRJEB3645 | ENA

Parabacteroides distasonis TSDC16.1-1.1

Project description:Strain Parabacteroides distasonis TSDC16.1-1.1 (species Parabacteroides distasonis) was isolated from the fecal microbiota of a USA female at time point zero . The species name was assigned by genome clustering.

| PRJEB3644 | ENA

Parabacteroides distasonis ameliorates insulin resistance via activation of intestinal GPR109a

Project description:Gut microbiota plays a key role in insulin resistance (IR). Here we perform a case-control study of Chinese adults (ChiCTR2200065715) and identify that Parabacteroides distasonis is inversely correlated with IR. Treatment with P. distasonis improves IR, strengthens intestinal integrity, and reduces systemic inflammation in mice. We further demonstrate that P. distasonis-derived nicotinic acid (NA) is a vital bioactive molecule that fortifies intestinal barrier function via activating intestinal G-protein-coupled receptor 109a (GPR109a), leading to ameliorating IR. We also conduct a bioactive dietary fiber screening to induce P. distasonis growth. Dendrobium officinale polysaccharide (DOP) shows favorable growth-promoting effects on P. distasonis and protects against IR in mice simultaneously. Finally, the reduced P. distasonis and NA levels were also validated in another human type 2 diabetes mellitus cohort. These findings reveal the unique mechanisms of P. distasonis on IR and provide viable strategies for the treatment and prevention of IR by bioactive dietary fiber.

2023-11-01 | MTBLS7943 | MetaboLights

Parabacteroides distasonis TSDC17.2-1.1

Project description:Strain Parabacteroides distasonis TSDC17.2-1.1 (species Parabacteroides distasonis) was isolated from the fecal microbiota of a USA female at time point zero (bacterial isolates were sequenced from this donor on day 0 and 49). The species name was assigned by genome clustering.

| PRJEB3769 | ENA

Parabacteroides distasonis TSDC19.2-1.8

Project description:Strain Parabacteroides distasonis TSDC19.2-1.8 (species Parabacteroides distasonis) was isolated from the fecal microbiota of a USA female at time point zero (bacterial isolates were sequenced from this donor on day 0 and 47). The species name was assigned by genome clustering.

| PRJEB3851 | ENA

Parabacteroides distasonis TSDC19.2-1.7

Project description:Strain Parabacteroides distasonis TSDC19.2-1.7 (species Parabacteroides distasonis) was isolated from the fecal microbiota of a USA female at time point zero (bacterial isolates were sequenced from this donor on day 0 and 47). The species name was assigned by genome clustering.

| PRJEB3850 | ENA

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