Genomics

Dataset Information

2

Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity


ABSTRACT: Bhlhe40 and Bhlhe41 transcription factors regulate alveolar macrophage self-renewal and identity

PROVIDER: PRJNA557178 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR9853610.fastq.gz Fastqsanger.gz
SRR9853620.fastq.gz Fastqsanger.gz
SRR9853630.fastq.gz Fastqsanger.gz
SRR9853611.fastq.gz Fastqsanger.gz
SRR9853621.fastq.gz Fastqsanger.gz
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Publications


Tissues in multicellular organisms are populated by resident macrophages, which perform both generic and tissue-specific functions. The latter are induced by signals from the microenvironment and rely on unique tissue-specific molecular programs requiring the combinatorial action of tissue-specific and broadly expressed transcriptional regulators. Here, we identify the transcription factors Bhlhe40 and Bhlhe41 as novel regulators of alveolar macrophages (AMs)-a population that provides the first  ...[more]

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