Project description:Alzheimer’s disease (AD) is an age-related neurodegenerative disorder in which neuroinflammation plays a critical function. Recurring viral infections and loss of immune competence increase risk for developing AD, yet the cellular and molecular mechanisms driving these immune changes are unknown. Here we performed mass cytometry of peripheral blood mononuclear cells and detected an immunologic signature of AD characterized by increased numbers of CD8+ T effector memory CD45RA+ (TEMRA) cells. CD8+ TEMRA cells were negatively associated with cognition and single cell RNA sequencing revealed their cytotoxic effector function. Strikingly, we discovered identical, shared T cell receptors (TCRs) of clonally expanded CD8+ TEMRA cells in cerebrospinal fluid (CSF) of three AD patients. Deep TCR sequencing, machine learning, and peptide screens identified the HLA-B*08:01-restricted Epstein-Barr virus trans-activator protein BZLF1 as the cognate antigen of a novel AD CSF TCR . These results provide the first evidence of clonal, antigen-specific T cells patrolling the intrathecal space of brains affected by age-related neurodegeneration

2019-11-04 | GSE135051 | GEO

Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [TEMRA]

2019-11-04 | GSE134576 | GEO

Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [CSF]

2019-11-04 | GSE134577 | GEO

Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-11-04 | GSE134578 | GEO

Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease.

Project description: Not available

| S-EPMC7445078 | biostudies-literature

Cerebrospinal fluid proteomic profiling reflects biological heterogeneity of early-onset Alzheimer's disease dementia

Project description:Cerebrospinal fluid proteomic profiling reflects biological heterogeneity of early-onset Alzheimer's disease dementia from The First Affiliated Hospital of USTC

2023-02-16 | PXD040216 | iProX

Human cerebrospinal fluid autoantibody lipid microarray profiling

Project description:This SuperSeries is composed of the following subset Series: GSE37664: Human cerebrospinal fluid autoantibody lipid microarray profiling (Fig. 1A) GSE37670: Human cerebrospinal fluid autoantibody lipid microarray profiling (Fig. 2A) GSE37826: Human cerebrospinal fluid autoantibody lipid microarray profiling (Fig. 2C) Refer to individual Series

2012-05-08 | E-GEOD-37830 | biostudies-arrayexpress

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