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Modular organization of the motor space in the mouse superior colliculus

ABSTRACT: Modular organization of the motor space in the mouse superior colliculus

PROVIDER: PRJNA557357 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9860330.fastq.gz	Fastqsanger.gz
	SRR9860340.fastq.gz	Fastqsanger.gz
	SRR9860331.fastq.gz	Fastqsanger.gz
	SRR9860341.fastq.gz	Fastqsanger.gz
	SRR9860332.fastq.gz	Fastqsanger.gz

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Modular organization of the motor space in the mouse superior colliculus

Project description:Modular organization of the motor space in the mouse superior colliculus

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Modular organization of the motor space in the mouse superior colliculus

Project description:In order to characterize the genetic diversity within the Stratum Griseum Intermediale (SGI), we screened gene expression by extracting RNA from sensory and motor layers of the Superior Colliculus (SC) at post-natal day (P)7.

2019-07-31 | GSE135082 | GEO

Effects of eye opening on gene expression in the superficial layers of the rat superior colliculus

Project description:We performed RNA-seq on six samples of P20 Sprague Dawley rat superior colliculus, three control rats that underwent eye opening at P14 until P20 and three deprived rats which had their eyes glued closed from P14 until P20. Each sample was created from two pooled colliculi. RNA-seq of the superior colliculus with and without long term light deprivation.

2015-09-09 | E-GEOD-72787 | biostudies-arrayexpress

Mapping Visual Functions onto Molecular Cell Types in the Mouse Superior Colliculus

Project description:To facilitate investigation of function, connectivity, and development of superficial superior colliculus (sSC), we identified 28 neuron subtypes and subtype-enriched marker genes from tens of thousands of adult mouse sSC neurons

2023-04-21 | GSE223155 | GEO

Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus

Project description:Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus

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Effects of eye opening on gene expression in the superficial layers of the rat superior colliculus

2015-09-09 | GSE72787 | GEO

Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus – Pten

Project description:Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus – Pten

| PRJNA1026955 | ENA

Chronic chemogenetic activation of the superior colliculus in glaucomatous mice: local and retrograde molecular signature

Project description:One important facet of the glaucoma pathology is axonal damage, which ultimately disrupts the connection between the retina and its postsynaptic targets. The concurrent loss of retrograde support interferes with the functionality and survival of the retinal ganglion cells (RGCs). Con-versely, previous research has shown that stimulation of neuronal activity in a primary retinal target area—i.e., the superior colliculus— promotes RGC survival in an acute mouse model of glaucoma. To build further on this observation, we applied repeated chemogenetics in the superior colliculus of a more chronic model of glaucoma—i.e., the microbead occlusion model—and per-formed bulk RNA sequencing on collicular lysates and isolated RGCs. Our study revealed that chronic target stimulation upon glaucomatous injury phenocopies the a priori expected molecular response: growth factors were pinpointed as essential transcriptional regulators both in the locally stimulated tissue and in distant, unstimulated RGCs. Strikingly, and although the RGC tran-scriptome revealed an enrichment of pro-survival signaling pathways, functional rescue of injured RGCs was not achieved.

2022-06-15 | GSE202012 | GEO

Three-Dimensional Representation of Motor Space in the Mouse Superior Colliculus.

Project description:From the act of exploring an environment to that of grasping a cup of tea, animals must put in register their motor acts with their surrounding space. In the motor domain, this is likely to be defined by a register of three-dimensional (3D) displacement vectors, whose recruitment allows motion in the direction of a target. One such spatially targeted action is seen in the head reorientation behavior of mice, yet the neural mechanisms underlying these 3D behaviors remain unknown. Here, by developing a head-mounted inertial sensor for studying 3D head rotations and combining it with electrophysiological recordings, we show that neurons in the mouse superior colliculus are either individually or conjunctively tuned to the three Eulerian components of head rotation. The average displacement vectors associated with motor-tuned colliculus neurons remain stable over time and are unaffected by changes in firing rate or the duration of spike trains. Finally, we show that the motor tuning of collicular neurons is largely independent from visual or landmark cues. By describing the 3D nature of motor tuning in the superior colliculus, we contribute to long-standing debate on the dimensionality of collicular motor decoding; furthermore, by providing an experimental paradigm for the study of the metric of motor tuning in mice, this study also paves the way to the genetic dissection of the circuits underlying spatially targeted motion.

| S-EPMC5988568 | biostudies-literature

Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus – Pten

Project description:The superior colliculus (SC) in the mammalian midbrain is essential for multisensory integration and is composed of a rich diversity of excitatory and inhibitory neurons and glia. The developmental principles directing the generation of SC cell-type diversity are however not understood. Here we pursued systematic cell lineage tracing in silico and in vivo, preserving full spatial information, using genetic MADM (Mosaic Analysis with Double Markers)-based clonal analysis with single-cell sequencing (MADM-CloneSeq). The analysis of clonally-related cell lineages revealed that radial glial progenitor (RGP) cells in SC are exceptionally multipotent. Individual resident RGPs have the capacity to produce all excitatory and inhibitory SC neuron types, even at the stage of terminal division. While individual clonal units show no pre-defined cellular composition, the establishment of appropriate relative proportions of distinct neuronal types occurs in a PTEN-dependent manner. Collectively, our findings provide an inaugural framework at single RGP/cell level of the mammalian SC ontogeny

2023-11-03 | GSE245104 | GEO

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