Genomics

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Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing


ABSTRACT: Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing

PROVIDER: PRJNA557711 | ENA |

REPOSITORIES: ENA

Dataset's files

Source:
Action DRS
SRR9875920_1.fastq.gz Fastqsanger.gz
SRR9875920_2.fastq.gz Fastqsanger.gz
SRR9875930_1.fastq.gz Fastqsanger.gz
SRR9875930_2.fastq.gz Fastqsanger.gz
SRR9875921_1.fastq.gz Fastqsanger.gz
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Publications

Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing.

Zeng Yang Y   He Jian J   Bai Zhijie Z   Li Zongcheng Z   Gong Yandong Y   Liu Chen C   Ni Yanli Y   Du Junjie J   Ma Chunyu C   Bian Lihong L   Lan Yu Y   Liu Bing B  

Cell research 20190909 11


Tracing the emergence of the first hematopoietic stem cells (HSCs) in human embryos, particularly the scarce and transient precursors thereof, is so far challenging, largely due to the technical limitations and the material rarity. Here, using single-cell RNA sequencing, we constructed the first genome-scale gene expression landscape covering the entire course of endothelial-to-HSC transition during human embryogenesis. The transcriptomically defined HSC-primed hemogenic endothelial cells (HECs)  ...[more]

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