Project description:Here we used artificial selection to assimilate a seasonal wing color phenotype from a naturally plastic population of butterflies. Using SNP association and RNAseq we mapped three genes responsible for wing color fixation, including the color pattern supergene cortex. Combined with endocrine and chromatin accessibility assays, we found that the rapid transition of wing coloration from an environmentally determined trait to a fixed, genetic trait occurred through selection on cis-regulatory alleles of genes with wing-specific functions, not by changes in environmental detection or hormone signaling.

2020-12-08 | GSE135522 | GEO

Genomic architecture and evolution of a seasonal reaction norm [RNA-seq]

2020-12-08 | GSE135521 | GEO

Genomic architecture and evolution of a seasonal reaction norm [Hi-C]

2020-12-08 | GSE152997 | GEO

Genomic architecture and evolution of a seasonal reaction norm

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-12-08 | GSE135523 | GEO

Evolution of a predator-induced, nonlinear reaction norm.

Project description: Not available

| S-EPMC5577476 | biostudies-literature

Mechanisms of innate events during skin reaction following intradermal injection of seasonal influenza vaccine

Project description:The skin plays a crucial role in host defences against microbial attack and the innate cells must provide the immune system with sufficient information to organize these defences. This unique feature makes the skin a promising site for vaccine administration. Although cellular innate immune events during vaccination have been widely studied, initial events remain poorly understood. Our aim is to determine molecular biomarkers of skin innate reaction after intradermal (i.d.) immunization. Using an ex vivo human explant model from healthy donors, we investigated by NanoLC-MS/MS analysis and MALDI-MSI imaging, to detect innate molecular events (lipids, metabolites, proteins) few hours after i.d. administration of seasonal trivalent influenza vaccine (TIV). This multimodel approach allowed to identify early molecules differentially expressed in dermal and epidermal layers at 4 and 18 h after TIV immunization compared with control PBS. In the dermis, the most relevant network of proteins upregulated were related to cell-to-cell signaling and cell trafficking. The molecular signatures detected were associated with chemokines such as CXCL8, a chemoattractant of neutrophils. In the epidermis, the most relevant networks were associated with activation of antigen-presenting cells and related to CXCL10. Our study proposes a novel step-forward approach to identify biomarkers of skin innate reaction.

2020-01-29 | PXD017313 | Pride

Swift thermal reaction norm evolution in a key marine phytoplankton species.

Project description: Not available

| S-EPMC5039328 | biostudies-literature