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Transgenerational self-reconstruction of disrupted chromatin organization after exposure to an environmental stressor in mice

ABSTRACT: Transgenerational self-reconstruction of disrupted chromatin organization after exposure to an environmental stressor in mice

PROVIDER: PRJNA562316 | ENA |

REPOSITORIES: ENA

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Transgenerational self-reconstruction of disrupted chromatin organization after exposure to an environmental stressor in mice

Project description:Exposure to environmental stressors is known to increase disease susceptibility in unexposed descendants in the absence of detectable genetic mutations. The mechanisms mediating environmentally-induced transgenerational disease susceptibility are poorly understood. We showed that great-great-grandsons of female mice exposed to tributyltin (TBT) throughout pregnancy and lactation were predisposed to obesity due to altered chromatin organization that subsequently biased DNA methylation and gene expression. Here we analyzed DNA methylomes and transcriptomes from tissues of animals ancestrally exposed to TBT spanning generations, sexes, ontogeny, and cell differentiation state. We found that TBT elicited concerted alterations in the expression of “chromatin organization” genes and inferred that TBT-disrupted chromatin organization might be able to self-reconstruct transgenerationally. We also found that the location of “chromatin organization” and “metabolic” genes is biased similarly in mouse and human genomes, suggesting that exposure to environmental stressors in different species could elicit similar phenotypic effects via self-reconstruction of disrupted chromatin organization.

2019-08-28 | GSE136377 | GEO

Transgenerational Self-Reconstruction of Disrupted Chromatin Organization After Exposure To An Environmental Stressor in Mice.

Project description: Not available

| S-EPMC6736928 | biostudies-literature

Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals

Project description:This SuperSeries is composed of the following subset Series: GSE25895: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (dye swap) GSE25896: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (Affymetrix) GSE25897: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (small RNA) GSE25898: Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (meDIP) Refer to individual Series

2011-01-14 | E-GEOD-25899 | biostudies-arrayexpress

Environmental Toxicants Induce Epigenetic Transgenerational Inheritance of Ovarian Disease

Project description:The epigenetic transgenerational actions of environmental toxicants and relevant mixtures on ovarian disease was investigated with the use of a fungicide, a pesticide mixture, a plastic mixture, dioxin and a hydrocarbon mixture. After transient exposure of an F0 gestating female rat during embryonic gonadal sex determination, the F1, F2 and F3 generation progeny adult onset ovarian disease was assessed. Transgenerational disease phenotypes observed included an increase in cysts resembling human polycystic ovarian disease (PCO) and a decrease in the ovarian primordial follicle pool size resembling premature ovarian failure (POF). The F3 generation granulosa cells were isolated and found to have a transgenerational effect on the transcriptome and epigenome (differential DNA methylation). Epigenetic biomarkers for environmental exposure and associated gene networks were identified. Epigenetic transgenerational inheritance of ovarian disease states were induced by different classes of environmental compounds suggesting a role of environmental epigenetics in ovarian disease etiology. We used transcriptome microarray analysis to determine genes expressed differentially between F3 control and F3 vinclozolin lineage rat ovary granulosa cell and see which genes might be connected to or cause observed ovary diseases RNA samples from granulosa cell of 3 F3-control lineage groups are compared to granulosa cell of 3 F3-vinclozolin lineage groups

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Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (Affymetrix)

Project description:Epigenetic information can be inherited through the mammalian germline, and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for genes in mice that responded to paternal diet. Characterising the change in RNA expression in sperm in response to different paternal diets. Examination of the effect of different diets, control diet, low-protein diet and caloric-restriction diet, on the RNA expression in the sperm. 8 samples: 3 are control diets and 2 are low protein diets 1 caloric restriction diet, and 2 samples from Epidydimal tissue.

2011-01-14 | E-GEOD-25896 | biostudies-arrayexpress

Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (meDIP)

Project description:Epigenetic information can be inherited through the mammalian germline, and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for genes in mice that responded to paternal diet. As part of this analysis, we chracterise the changes in sperm cytosine methylation in response to different diets. Characterizing the RNA exression changes in livers of offspring mice in response to the paternal diet, comparing between low-protein diet and control-diet. Examination the effect of 3 different paternal diets, control diet, Caloric Restriction and low-protein diet, on sperm cytosine methylation.

2011-01-14 | E-GEOD-25898 | biostudies-arrayexpress

Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (dye swap)

Project description:Epigenetic information can be inherited through the mammalian germline, and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for genes in mice that responded to paternal diet. Characterizing the RNA exression changes in livers of offspring mice in response to the paternal diet, comparing between low-protein diet and control-diet. Examination of the effect of 2 different paternal diets, control diet and low-protein diet, on the mRNA expression in the liver of the offsprinngs. 26 samples: including Control diet vs. Low-protein (with dye swap), and Control diet vs. Low-protein after fasting the mice.

2011-01-14 | E-GEOD-25895 | biostudies-arrayexpress

Environmental Toxicants Induce Epigenetic Transgenerational Inheritance of Ovarian Disease [Affymetrix]

2012-03-01 | GSE33423 | GEO

Germ cell epigenetic instability in the Mtrr mouse model of transgenerational epigenetic inheritance

Project description:Folate metabolism is important for the generation of methyl groups required for cellular methylation reactions. Mice with a hypomorphic mutation in the gene Mtrr have disrupted folate metabolism and show transgenerational inheritance of developmental abnormalities. We sought to explore if DNA methylation patterns in the sperm of Mtrr mice may be disrupted. Therefore we performed MeDIP-seq on sperm collect from males with the Mtrr mutation (either heterozygous (Mtrr +/gt) or homozygous mutants (Mtrr gt/gt)), males ancestrally exposed to the Mtrr mutation (Mtrr +/+) and C57Bl/6J control males. C57Bl/6J males were used as controls as they have the same genetic background as the mice with Mtrr mutation.

2021-04-06 | E-MTAB-8533 | biostudies-arrayexpress

Paternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (Affymetrix)

2011-01-14 | GSE25896 | GEO

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