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Copy Number Variations identified in 225 Diffuse Large B-Cell Lymphoma tumors

ABSTRACT: Copy Number Variations identified in 225 Diffuse Large B-Cell Lymphoma tumors

PROVIDER: PRJNA564130 | ENA |

REPOSITORIES: ENA

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Copy Number Variations identified in 225 Diffuse Large B-Cell Lymphoma tumors

Project description:Copy Number Variations (CNVs) were identified performing Comparative Genomic Hybridization (CGH) on 225 patients after whole-genome amplification, using Agilent SurePrint G3 4x180K microarrays. CNVs were further integrated with gene expression (Affymetrix U133+2 arrays) and mutations (targeted DNA resequencing). Complete description of the methods, array quality checks and called segments are available as supplemental material in the corresponding publication.

2019-10-24 | GSE136962 | GEO

Expression data and Copy Number Variations from Diffuse Large B Cell Lymphoma (DLBCL) patients

Project description:Expression data and Copy Number Variations from Diffuse Large B Cell Lymphoma (DLBCL) patients

| PRJNA564132 | ENA

Paired copy number analysis of Diffuse Large B Cell Lymphoma [OncoScan]

Project description:Copy number analysis can be useful for assessing prognosis in diffuse large B cell lymphoma (DLBCL). We analyzed copy number data from tumor samples of 60 patients diagnosed with DLBCL de novo and their matched normal samples. We detected a total of 63 recurrent copy number alterations (CNAs), including 33 gains, 30 losses, and nine recurrent acquired copy number neutral loss of heterozygosity (CNN-LOH). Interestingly, 20% of cases acquired CNN-LOH of 6p21 locus, which involves the HLA region. In normal cells there were no CNAs but we observed CNN-LOH involving some key lymphoma regions such as 6p21 and 9p24.1 (5%) and 17p13.1 (2.5%) in DLBCL patients. Furthermore, a model with some specific CNA was able to predict the subtype of DLBCL, 1p36.32 and 10q23.31 losses being restricted to germinal center B cell-like (GCB) DLBCL. In contrast, 8p23.3 losses and 11q24.3 gains were strongly associated with the non-GCB subtype. A poor prognosis was associated with biallelic inactivation of TP53 or 18p11.32 losses, while prognosis was better in cases carrying 11q24.3 gains, which includes ETS1 and FLI1 genes. In summary, CNA abnormalities identify specific DLBCL groups, and we describe CN-LOH in germline cells from DLBCL patients that are associated with genes that probably play a key role in DLBCL development.

2016-01-22 | GSE71386 | GEO

Expression data and Copy Number Variations from Diffuse Large B Cell Lymphoma (DLBCL) patients

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-09-05 | GSE136971 | GEO

Paired copy number analysis of DLBCL Diffuse Large B Cell Lymphoma [SNP 6.0 Array]

2016-01-22 | GSE71389 | GEO

Copy Number Variations in Genomic Disorders

Project description:Copy Number Variations in Genomic Disorders

| PRJNA75521 | ENA

Paired copy number analysis of Diffuse Large B Cell Lymphoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-01-22 | GSE71394 | GEO