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Transcriptional profiling of neurons in the midbrain of a Lhx5-TRAP (DT154) mouse line

ABSTRACT: Transcriptional profiling of neurons in the midbrain of a Lhx5-TRAP (DT154) mouse line

PROVIDER: PRJNA564515 | ENA |

REPOSITORIES: ENA

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Transcriptional profiling of neurons in the midbrain of a Lhx5-TRAP (DT154) mouse line

Project description:TRAP translational profiling is a method that allows investigators to genetically characterize specific cell types in complex tissues such as mouse brain. Using this technique we obtained RNA-Seq data from actively translating transcripts present in neurons in the midbrain of adult Lhx5-EGFP/Rpl10a (DT154) mice.

2019-09-10 | GSE137078 | GEO

Transcriptional profiling of neurons in the hypothalamus of a Lhx5-TRAP (DT154) mouse line

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Transcriptional profiling of neurons in the midbrain of a Stard8-TRAP (ES2342) mouse line

Project description:Transcriptional profiling of neurons in the midbrain of a Stard8-TRAP (ES2342) mouse line

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Transcriptional profiling of neurons in the hypothalamus of a Lhx5-TRAP (DT154) mouse line

Project description:Transcriptional profiling of neurons in the hypothalamus of a Lhx5-TRAP (DT154) mouse line

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Transcriptional profiling of neurons in the hypothalamus and midbrain of an Slc17a6-TRAP (JX883) mouse line

Project description:Transcriptional profiling of neurons in the hypothalamus and midbrain of an Slc17a6-TRAP (JX883) mouse line

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Generation and characterization of a mouse line for monitoring translation in dopaminergic neurons.

Project description:We developed a mouse line targeting midbrain dopamine neurons for Translating Ribosome Affinity Purification (TRAP). Here, we briefly report on the basic characterization of this mouse line including confirmation of expression of the transgene in midbrain dopamine neurons and validation of its effectiveness in capturing mRNA from these cells. We also report a translational profile of these neurons which may be of use to investigators studying the gene expression of these cells. Finally, we have donated the line to Jackson Laboratories for distribution and use in future studies.

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Transcriptional profiling of neurons in an Slc17a6-TRAP (JX883) mouse line

Project description:Transcriptional profiling of neurons in an Slc17a6-TRAP (JX883) mouse line

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Transcriptome profiling of DA neurons, human midbrain-like organoids and prenatal midbrain

Project description:Recent advances in three dimensional (3D) culture systems have led to the generation of brain organoids that share resemblance to different parts of the human brains; however, a 3D organoid model of the midbrain that contains functional midbrain dopaminergic (mDA) neurons has not been reported. In this study, we develop a method to differentiate human PSCs into a large multicellular organoid-like structure that contains distinct layers of neuronal cells with a transcriptomic profile that resembles human prenatal midbrain. Importantly, we detected electrically active and functionally mature mDA neurons, and dopamine production in our 3D midbrain-like organoids (MLOs). In contrast to human mDA neurons generated using non-3D methods or in the MLOs generated from mouse embryonic stem cells, our human MLOs uniquely produced neuromelanin-like granules that were structurally similar to those isolated from human substantia nigra tissues. Thus our MLOs bearing features of the human midbrain may provide a novel tractable in vitro system to study the human midbrain and its related diseases.

2016-08-24 | E-MTAB-4868 | biostudies-arrayexpress

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