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Allele-specific 4C-seq of rs2836411 located in the ERG gene in HUVEC and HASMCs

ABSTRACT: Allele-specific 4C-seq of rs2836411 located in the ERG gene in HUVEC and HASMCs

PROVIDER: PRJNA565014 | ENA |

REPOSITORIES: ENA

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Allele-specific 4C-seq of rs2836411 located in the ERG gene in HUVEC and HASMCs

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Expression data from ERG Si treated and Control HUVEC cells

Project description:ERG (Ets Related Gene) is an ETS transcription factor that was originally described for its role in a number of human cancers. Our preliminary data demonstrate that ERG exhibits a highly EC restricted pattern of expression in cultured primary cells and several adult tissues including the heart, lung, and brain. In response to inflammatory stimuli, such as TNF-alpha, we observed a marked reduction of ERG expression in EC. To further define the role of ERG in the regulation of normal EC function we used RNA interference to knockdown ERG. Knockdown of ERG in human umbilical vein EC (HUVEC) using siRNA was associated with the reduction of a number known ERG targets. Keywords: SIRNA Functional Role

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Gene expression profiling of Human Umbilical Vein Endothelial Cells (HUVEC) after treatment with Erg or control antisense (GeneBloc)

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The transcription factor ERG regulates super-enhancers in endothelial cells [ERG siRNA]

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The transcription factor ERG regulates super-enhancers in endothelial cells [ERG ChIP-seq]

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The tRNA derived fragments (tRFs) expression profiles in human aortic smooth muscle cells (HASMCs)

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Dynamic regulation of VEGF-inducible genes by an ERK-ERG-p300 transcriptional network

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