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The transcriptomic landscape of MAIT cell development in the thymus (NN41 RNAseq data set)

ABSTRACT: The transcriptomic landscape of MAIT cell development in the thymus (NN41 RNAseq data set)

PROVIDER: PRJNA565221 | ENA |

REPOSITORIES: ENA

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The transcriptomic landscape of MAIT cell development in the thymus (C006 RNAseq data set)

Project description:We report the transcriptomic landscape of MAIT cell development by examining thymic immature stage 1 and mature stage 3 MAIT cells from mouse thymus, and thymic immature stage 1, stage 2 mature stage 3 MAIT cells from human thymus using RNAseq.

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The transcriptomic landscape of MAIT cell development in the thymus (NN41 RNAseq data set)

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The transcriptomic landscape of MAIT cell development in the thymus (C006 RNAseq data set)

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Project description:The transcriptomic landscape of MAIT cell development in the thymus

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Microarray expression profiling of MAIT subsets isolated from thymus of B6-MAIT/CAST mice, as compared to single positive CD4 or CD8 conventional T cells.

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Project description:Mucosal associated invariant T (MAIT) cells, already differentiated and located at mucosal sites, are critical in the body’s first wave of defenses against invading pathogens. Bcl11b KO MAIT cells fail to be maintained both in the thymus and peripheral organs. Furthermore, MAIT cells fail to fully develop in the thymus without Bcl11b, failing to upregulate RORγt, and that phenotype remains in the lungs and livers of these mice. Bcl11b deletion in MAIT cells causes dramatic shifts in the activation and TH17 programs, due to the binding of Bcl11b in many of those genes, which we have seen in the human MAIT cells. MAIT cells rely on PLZF and RORγt for their development and function, while also heavily relying on Bcl11b. These data show the key interplay of Bcl11b with PLZF and RORγt in a T cell leading to its development and necessary function to protect the body against diseases.

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