Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Alteration of genome folding via engineered transposon insertion [HiC]

ABSTRACT: Alteration of genome folding via engineered transposon insertion [HiC]

PROVIDER: PRJNA565259 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Alteration of genome folding via engineered transposon insertion [HiC]

Project description:Mammalian chromosomes are partitioned into contact domains that can be conserved as functional units in evolution. Disruptions of domains can result from perturbed CTCF, cohesin, or chromosomal rearrangements. However, to what extent domains can be created de novo has not been explored in depth. Here, using a gain-of-function approach leveraging genome editing and Hi-C, we examined whether, and how, a putative boundary element can function to organize de novo domains in the context of multiple ectopic insertion sites. We subsequently dissected the distinct roles of the CTCF binding site and the transcription start site within the insertion element in changing genome folding.

2020-03-14 | GSE137372 | GEO

Alteration of genome folding via engineered transposon insertion

Project description:Alteration of genome folding via engineered transposon insertion

| PRJNA565254 | ENA

Alteration of genome folding via engineered transposon insertion [CaptureC]

Project description:Alteration of genome folding via engineered transposon insertion [CaptureC]

| PRJNA565260 | ENA

Alteration of genome folding via engineered transposon insertion [RNA-seq]

Project description:Alteration of genome folding via engineered transposon insertion [RNA-seq]

| PRJNA565257 | ENA

Alteration of genome folding via engineered transposon insertion [CaptureC]

2020-03-14 | GSE137373 | GEO