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Epithelial Tumour Suppressor ELF3 is a Lineage-Specific Amplified Oncogene in Lung Adenocarcinoma

ABSTRACT: Epithelial Tumour Suppressor ELF3 is a Lineage-Specific Amplified Oncogene in Lung Adenocarcinoma

PROVIDER: PRJNA565706 | ENA |

REPOSITORIES: ENA

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Epithelial Tumour Suppressor ELF3 is a Lineage-Specific Amplified Oncogene in Lung Adenocarcinoma

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-10-23 | GSE137481 | GEO

Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma.

Project description: Not available

| S-EPMC6882813 | biostudies-literature

Expression profiling of isogenic A549 cell lines with and without ELF3 knock-down

Project description:Gene function in cancer is often cell type-specific. The epithelial cell-specific transcription factor ELF3 is a documented tumour suppressor in many epithelial tumours yet displays oncogenic properties in others. Here, we show that ELF3 is an oncogene in the adenocarcinoma subtype of lung cancer (LUAD), providing genetic, functional, and clinical evidence of subtype specificity. We discover a region of focal amplification at chromosome 1q32.1 encompassing the ELF3 locus in LUAD which is absent in the squamous subtype. Gene dosage and promoter hypomethylation affect the locus in up to 80% of LUAD analysed. ELF3 expression was required for tumour growth and a pan-cancer expression network analysis supports its subtype and tissue specificity. We further show that ELF3 displays strong prognostic value in LUAD but not LUSC. We conclude that, contrary to many other tumours of epithelial origin, ELF3 is an oncogene and putative therapeutic target in LUAD.

2019-10-23 | GSE137479 | GEO

Project description:Epithelial Tumour Suppressor ELF3 is a Lineage-Specific Amplified Oncogene in Lung Adenocarcinoma

| PRJNA563664 | ENA

Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer

Project description:Lung cancer is a leading cause of cancer death, where the amplification of oncogenes contributes to tumorigenesis. Genomic profiling of 128 lung cancer cell lines and tumors revealed frequent focal DNA amplification at cytoband 14q13.3, a locus not amplified in other tumor types. The smallest region of recurrent amplification spanned the homeobox transcription factor TITF1 (also known as NKX2-1), previously linked to normal lung development and function. When amplified, TITF1 exhibited increased expression at both the RNA and protein level. siRNA-mediated knockdown of TITF1 in lung cancer cell lines with amplification led to reduced cell proliferation, manifested by both decreased cell-cycle progression and increased apoptosis. Our findings indicate that TITF1 amplification and overexpression contribute to lung cancer cell proliferation rates and survival, and implicate TITF1 as a lineage-specific oncogene in lung cancer. This SuperSeries is composed of the following subset Series: GSE9994: Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer: Expression Arrays GSE10025: Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer: aCGH Arrays Keywords: SuperSeries Refer to individual Series

2008-02-29 | E-GEOD-9995 | biostudies-arrayexpress

Expression profiling analysis of an inducible ELF3-expressing and control human bile duct cells [inducible ELF3]

Project description:An immortalized normal epithelial cell line of common bile duct origin (HBDEC2 cells) was established. An inducible ELF3-expressing was generated by infection with the retrovial vector pRetroX-TetOne-Puro-ELF3-flag, expressing ELF3 fused to a flag-tag.

2020-08-27 | GSE148107 | GEO

DNA methylation profiling of lung adenocarcinomas and patient-matched non-malignant lung

2019-10-23 | GSE139032 | GEO

DNA copy number profiling of lung adenocarcinomas and patient-matched non-malignant lung

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RNA-Seq and ChIP-Seq profiling of ELF3, an prion-like domain-containig in ELF3 that functions as a thermosensor in Arabidopsis.

Project description:Temperature is a major environmental variable governing plant growth and development. ELF3 contains a polyglutamine (polyQ) repeat 8–10, embedded within a predicted prion domain (PrD). We find the length of the polyQ repeat correlates with thermal responsiveness. Plants from hotter climates appear to have lost the PrD domain, and these versions of ELF3 are stable at high temperature and lack thermal responsiveness. ELF3 temperature sensitivity is also modulated by the levels of ELF4, indicating that ELF4 can stabilise ELF3 function. This RNA-Seq dataset provides evidence for the hypothetical ELF3 function of temperature sensing .

2020-06-21 | GSE137264 | GEO

Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences.

Project description: Not available

| S-EPMC3040683 | biostudies-literature