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Transciptome analysis of human aortic smooth muscle cells (HASMCs) with 2-hydroxypropyl-β-cyclodextrin (HPbCD) treatment

ABSTRACT: Transciptome analysis of human aortic smooth muscle cells (HASMCs) with 2-hydroxypropyl-β-cyclodextrin (HPbCD) treatment

PROVIDER: PRJNA565961 | ENA |

REPOSITORIES: ENA

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Transciptome analysis of human aortic smooth muscle cells (HASMCs) with 2-hydroxypropyl-β-cyclodextrin (HPbCD) treatment

Project description:HASMCs were treated with HPbCD (10mg/kg) for 24 hours and harvest for RNA sequence.

2020-11-21 | GSE137576 | GEO

Transciptome analysis of human aortic smooth muscle cells (HASMCs) with BAF60c knockdown

Project description:HASMCs were transfected with BAF60c siRNA (siBAF60c, 20um) or control siRNA (siControl) for 48 hours, and serum-starved for 24 hours , followed by RNA-sequencing

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Hydroxypropyl-β-cyclodextrin spikes local inflammation that induces Th2 and Tfh responses to the coadministered antigen

Project description:Gene expression data from mouse organs after hydroxypropyl-β-cyclodextrin injection Cyclodextrins are commonly used as a safe excipient to enhance the solubility and bioavailability of hydrophobic pharmaceutical agents. In this study, we reprofiled hydroxypropyl-β-cyclodextrin (HP-β-CD) as a vaccine adjuvant, and found that it acts as a potent and unique adjuvant.

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Hydroxypropyl-Î²-cyclodextrin spikes local inflammation that induces Th2 and Tfh responses to the coadministered antigen

Project description:Gene expression data from mouse organs after hydroxypropyl-Î²-cyclodextrin injection Cyclodextrins are commonly used as a safe excipient to enhance the solubility and bioavailability of hydrophobic pharmaceutical agents. In this study, we reprofiled hydroxypropyl-Î²-cyclodextrin (HP-Î²-CD) as a vaccine adjuvant, and found that it acts as a potent and unique adjuvant. C57BL/6J mice (6 week old, male, n = 3) were injected i.d. or i.p. with a total volume of 200 micro liter of 30% HP-Î²-CD in PBS. The vehicle-control mice (n = 3) were injected with the same volume of PBS. After 6 h, the inguinal LNs, Liver, and Spleen were removed (within one hour for all samples) and global gene expression was obtained by Affymetrix GeneChip.

2015-02-15 | E-GEOD-63332 | biostudies-arrayexpress

The tRNA derived fragments (tRFs) expression profiles in human aortic smooth muscle cells (HASMCs)

Project description:To explore the potential involvement of tRNA derived fragments (tRFs) in the human aortic vascular smooth muscle cells (HASMCs), we conducted tRFs profiling in three pairs of differentiated HASMCs (treated with PBS) and dedifferentiated HASMCs (treated with PDGF-BB 50 ng/ml) by microarray. Our results showed that tRFs were aberrantly expressed in dedifferentiated HASMCs compared with differentiated HASMCs and provided potential targets for novel insights into VSMC differentiation or vascular remodeling diseases.

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Identity transcript factor EB (TFEB) target genes in human aortic smooth muscle cells (HASMCs)

Project description:Using ChIP-Seq technology, we identitied novel target of TFEB in HASMCs.

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Transciptomic analysis of human aortic smooth muscle cells (HASMCs) with BAF60a overexpression

Project description:We used NGS-derived transcriptome profiling (RNA-seq) to compare the transcriptional difference between human aortic smooth muscle cells (HASMCs) infected with 20MOI adenovirus encoding human BAF60a (AdBAF60a) or GFP (AdGFP)

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Transciptomic analysis of human aortic smooth muscle cells (HASMCs) with BAF60a knockdown

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Genome-wide maps of chromatin state changes in BAF60a deficient human aortic smooth muscle cells (HASMCs)

Project description:We compared BRG1 binding and histone modification states between siControl and siBAF60a transfected human aortic smooth muscle cells (HASMCs) through ChIP sequencing.

2020-11-21 | GSE153446 | GEO

Genome-wide maps of chromatin state changes in BAF60c deficient human aortic smooth muscle cells (HASMCs)

Project description:We compared BRG1 binding and 4 histone modification states between siControl and siBAF60c transfected human aortic smooth muscle cells (HASMCs) through ChIP sequencing (ChIP-seq).

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