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Sex chromosomes affect gene expression of autoantigen specific CD4+ T cells in B6 gonadal males.

ABSTRACT: Sex chromosomes affect gene expression of autoantigen specific CD4+ T cells in B6 gonadal males.

PROVIDER: PRJNA573079 | ENA |

REPOSITORIES: ENA

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Sex chromosomes affect gene expression of autoantigen specific CD4+ T cells in B6 gonadal males.

Project description:To determine the role of sex chromsomes in sex differences of autoimmune disease, we used high throughput RNA sequencing to analyze the transciptomes of autoantigen specific CD4+ T cells from XX and XY- mice using the “four core genotypes” mouse model. We found higher expression of several X genes in the XY- genotype compared to XX, suggesting a difference in DNA methylation of these genes between Xp and Xm. In a hypothesis driven targeted approach, we investigated two immunomodulatory X genes, Tlr7 and FoxP3 and found that the promoter regions of both genes had more DNA methylation on the Xp than Xm, and that both genes had higher expression in autoantigen stimulated CD4+ T cells from XY- compared to XX mice. This study provides new insights regarding how sex chromsomes affect gene expression and cause sex differences in autoimmune disease.

2019-12-10 | GSE137793 | GEO

Sex chromsomes affect gene expression of healthy CD4+ T cells in B6 gonadal males

Project description:Sex chromsomes affect gene expression of healthy CD4+ T cells in B6 gonadal males

| PRJNA578120 | ENA

Sex chromsomes affect gene expression of healthy CD4+ T cells in B6 gonadal males

Project description:To determine the role of sex chromsomes in sex differences of autoimmune disease, we used high throughput RNA sequencing to analyze the transciptomes of CD4+ T cells stimuated with antiCD3/CD28 from XXSry and XY-Sry mice using the “four core genotypes” mouse model. We found higher expression of several X genes in the XY- genotype compared to XX, suggesting a difference in DNA methylation of these genes between Xp and Xm. In a hypothesis driven targeted approach, we investigated two immunomodulatory X genes, Tlr7 and FoxP3 and found that the promoter regions of both genes had more DNA methylation on the Xp than Xm, and that both genes had higher expression in autoantigen stimulated CD4+ T cells from XY- compared to XX mice. This study provides new insights regarding how sex chromsomes affect gene expression and cause sex differences in autoimmune disease.

2019-12-10 | GSE139034 | GEO

Sex chromosomes affect gene expression of healthy CD4+ T cells in B6 gonadal females.

Project description:To determine the role of sex chromsomes in sex differences of autoimmune disease, we used high throughput RNA sequencing to analyze the transciptomes of CD4+ T cells stimuated with antiCD3/CD28 from XX and XY- mice using the “four core genotypes” mouse model. We found higher expression of several X genes in the XY- genotype compared to XX, suggesting a difference in DNA methylation of these genes between Xp and Xm. In a hypothesis driven targeted approach, we investigated two immunomodulatory X genes, Tlr7 and FoxP3 and found that the promoter regions of both genes had more DNA methylation on the Xp than Xm, and that both genes had higher expression in autoantigen stimulated CD4+ T cells from XY- compared to XX mice. This study provides new insights regarding how sex chromsomes affect gene expression and cause sex differences in autoimmune disease.

2019-12-10 | GSE137791 | GEO

Murine Liver Cells: Control B6 males vs. little (GH-deficient) and Tfm (AR-null) males

2014-08-09 | GSE60253 | GEO

Sex chromosomes affect gene expression of healthy CD4+ T cells in B6 gonadal females.

Project description:Sex chromosomes affect gene expression of healthy CD4+ T cells in B6 gonadal females.

| PRJNA573077 | ENA

Murine Liver Cells: Control B6 males vs. little (GH-deficient) and Tfm (AR-null) males

Project description:Transcriptional profiling of mouse whole liver comparing control WT B6 mice with B6 growth hormone-deficient little, B6 androgen receptor-null Tfm mice, and STAT5b KOs normalized to WT on B6 and BALB/c backgrounds. All animals were 10-week-old males initiated with DEN. Oberley et al. Molecular carcinogenesis 2014 May 17. doi: 10.1002/mc.22165. Three-condition experiment, WT vs. little and Tfm livers. Biological replicates: 3 control replicates, 3 mutant replicates. Little and Tfm normalized to WTa, B6 STAT5b KO

2014-08-09 | E-GEOD-60253 | biostudies-arrayexpress

Sex chromsomes affect gene expression of autoantigen specific CD4+ T cells.

2019-08-21 | GSE121705 | GEO

Sex chromsomes affect gene expression of autoantigen specific CD4+ T cells

2019-08-21 | GSE121292 | GEO

Autoantigen promotes progression to aggressive TCL1 leukemia

Project description:Activated BCR signaling in Murine CLL leukemia cells responsive to autoantigen phosphatidylcholine Murine CLL cells obtained from spleen and peritoneum were compared for the genetic signatures associated with autoantigen responsiveness

2013-05-01 | E-GEOD-45481 | biostudies-arrayexpress

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