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GR cistromes reprogramming by High Fat Diet [ChIP-seq: GR DEX]

ABSTRACT: GR cistromes reprogramming by High Fat Diet [ChIP-seq: GR DEX]

PROVIDER: PRJNA574072 | ENA |

REPOSITORIES: ENA

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GR cistromes reprogramming by High Fat Diet [ChIP-seq: GR DEX]

Project description:We mapped the genome-wide binding profiles of GR by using ChIP-Seq in livers from mice fed control or HFD diet after acute exogenous ligand (DEX) administration.

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GR cistromes reprogramming by High Fat Diet [RNA-seq]

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GR cistromes reprogramming by High Fat Diet [ChIP-seq H3K27ac]

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GR cistromes reprogramming by High Fat Diet [RNA-seq]

Project description:We mapped the genome-wide binding profiles of GR throughout the day/night cycle (ZT0-ZT4-ZT8-ZT12-ZT16-ZT20) by using ChIP-Seq in livers from control mice and mice fed High Fat Diet (HFD) for 12 weeks

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GR cistromes reprogramming by High Fat Diet [ChIP-seq H3K27ac]

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GR and BRG1 cistromes of murine primary bone marrow derived macrophages treated with LPS and Dex+LPS [ChIP-seq]

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Intestinal epithelial GR in response to DEX treatment

Project description:The goal of this project is to investigate the role of glucocorticoids and their receptor, glucocorticoid receptor (GR) , in intestinal stress response and tissue homeostasis.We generated a mouse model with specific deletion of GR in intestinal epithelium (GR iKO mice) and examined colonic transcriptomes of adrenalectomized (ADX) Flox control and GR iKO mice in response to dexamethasone (DEX) treatment by microarray analysis.

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Intestinal epithelial GR in response to DEX treatment

Project description:Intestinal epithelial GR in response to DEX treatment

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