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Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis [RIP-Seq]

ABSTRACT: Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis [RIP-Seq]

PROVIDER: PRJNA576884 | ENA |

REPOSITORIES: ENA

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Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis [RIP-Seq]

Project description:Metastasis is the primary cause of death of cancer patients. Dissecting mechanisms governing metastatic spread may uncover important tumor biology and/or yield promising therapeutic insights. Here we investigated the role of circular RNAs (circRNA) in metastasis, using melanoma as a model aggressive tumor. We identified silencing of Cerebellar Degeneration Related 1 (CDR1as), a regulator of the microRNA miR-7, as a hallmark of melanoma progression. We find that CDR1as depletion results from epigenetic silencing of its originating lincRNA, and promotes invasion in vitro and metastasis in vivo, through a miR-7-independent, IGF2BP3-mediated mechanism. Moreover, CDR1as levels identify cellular states associated with distinct therapeutic responses. Our study reveals functional, prognostic and predictive roles for CDR1as and expose circRNAs as key players in metastasis.

2020-01-13 | GSE138710 | GEO

Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis [RNA-Seq]

2020-01-13 | GSE138412 | GEO

Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis

Project description:Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis

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Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis [RNA-Seq]

Project description:Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis [RNA-Seq]

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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis.

Project description: Not available

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RIP-sequence of IGF2BP3 in Ishikawa cells

Project description:To explain the possible molecular mechanism underlying the oncogenic roles of IGF2BP3 in EC, we employed RNA immunoprecipitation (RIP) assays to identify the lncRNAs involved in the regulation of IGF2BP3 function. RIP experiments, high-throughput sequencing and data analysis were performed by Seqhealth Tech (Wuhan, China). RIP assays were carried out on Ishikawa cells. The cells were lysed, and the lysis samples for immunoprecipitation reactions were incubated with anti-IGF2BP3 antibody (ab177477, Abcam, USA) or rabbit IgG (Cell Signaling Technology). The library products were enriched, quantified and finally sequenced on the Illumina PE150 platform.One hundred ninety-one candidates as IGF2BP3-interacting lncRNAs were identified in the RIP-seq results.

2022-03-16 | GSE198620 | GEO

RNA immunoprecipitation (RIP) of IGF2BP3 from pancreatic cancer cell extracts cultured on fibronectin

Project description:IGF2BP3-bound transcripts were identified by RNA immunoprecipitation and sequencing (RIP-Seq) and bioinformatics analysis. A pancreatic cancer cell line S2-013 was cultured on fibronectin. We performed RIP of IGF2BP3 using anti-IGF2BP3 antibody from the fibronectin-stimulated S2-013 extracts, and identified the associated mRNAs using a next generation sequencer.

2016-11-09 | GSE47597 | GEO

Epigenetic silencing of CDR1as drives IGF2BP3-mediated melanoma invasion and metastasis

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-01-13 | GSE138711 | GEO

RIP-sequence of IGF2BP3 in Ishikawa cells

Project description:RIP-sequence of IGF2BP3 in Ishikawa cells

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IGF2BP3 controls cancer cell invasiveness by modulation RISC function

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2016-03-12 | E-GEOD-79147 | biostudies-arrayexpress

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