Project description:In mouse aorta endothelial cells, populations of endothelial vascular progenitor (EVP) and differentiated (D) cells could be identified by CD31 (lo/hi) and VEGFR2 (lo/hi) expression. These populations were FACS sorted and paired-end bulk RNA-sequencing was performed.

2019-05-27 | E-MTAB-7148 | biostudies-arrayexpress

Bulk RNA-seq of mouse neural stem and progenitor cells (NSPC) derived from embryonic stem cells, with allele-specific deletions of a Sox2 enhancer cluster

Project description:We have generated RNA-sequencing datasets of the regulome of mouse neural stem and progenitor cells derived from embryonic stem cells, with allele-specific deletions of Sox2 enhancer cluster regions. RNA-seq experiments were conducted to evaluate the regulatory function of Sox2 candidate enhancers in neural stem and progenitor cells.

2023-11-13 | GSE237775 | GEO

A Genome-Wide CRISPR Screen Identifies BRD4 as a Regulator of Cardiomyocyte Differentiation [in-vitro bulk RNA-seq]

Project description:We employed bulk RNA sequencing to interrogate the consequence of conditional BRD4 deletion in mouse embryonic stem cell (mESC)-derived cardiac progenitor cells.

2024-01-15 | GSE184919 | GEO

Bulk ATAC-seq of mouse neural stem and progenitor cells (NSPC) derived from embryonic stem cells, with biallelic Sox2 enhancer cluster deletions

Project description:We have generated ATAC-sequencing datasets of the regulome of mouse neural stem and progenitor cells derived from embryonic stem cells, with allele-specific deletions of Sox2 enhancer cluster regions. ATAC-seq experiments were conducted to evaluate the alterations in chromatin accessibility at candidate regulatory elements genome-wide in neural stem and progenitor cells with Sox2 enhancer loss-of-function.

2023-11-13 | GSE237777 | GEO

Expression data from mouse embryonic lung epithelial tip progenitor cells

Project description:Epithelial tip progenitor cells are an important epithelial progenitor population in the developing lung. At early stages of development they produce SOX2+ bronchiolar progenitor cells. At later stages of embryonic lung development they produce SOX2- alveolar progenitor cells. We purified the tip progenitor cells from early (E11.5, bronchiolar progenitor producing) and late (E17.5, alveolar progenitor producing) stages of mouse lung development and used Affymetrix microarrays to compare their gene expression profiles.

2016-08-31 | GSE75860 | GEO