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Effects of bacterial haemorrhagic septicemia on the immune response of Leiocassis longirostris (RNA-Seq)

ABSTRACT: Effects of bacterial haemorrhagic septicemia on the immune response of Leiocassis longirostris (RNA-Seq)

PROVIDER: PRJNA577906 | ENA |

REPOSITORIES: ENA

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Effects of bacterial haemorrhagic septicemia on the immune response of Leiocassis longirostris (microRNA-Seq)

Project description:Leiocassis longirostris is a common fish variety widely cultivated in China, however, bacterial haemorrhagic septicemia, which occurs easily during the breeding process, can cause great economic loss for farmers. To understand the immune response of L. longirostris to Aeromonas hydrophila infection, Illumina sequencing was employed to identify changes in the mRNA and miRNA in spleen tissue. In this study, a total of 92.16 and 95.61 million (M) high-quality transcriptome reads were generated from the control group (CG) and experimental group (EG) spleen samples, respectively, and 207 up-regulated and 185 down-regulated genes were identified. These genes were enriched in 29 GO terms and 30 KEGG pathways (P ≤ 0.05), including cytokine-cytokine receptor interaction and complement and coagulation cascades, with 17 up-regulated genes and 12 down-regulated genes in the EG relative to the CG. Based on the zebrafish genome, miRNA-seq identified a total of 343 miRNAs, of which 15 were up-regulated and 10 were down-regulated (fold-change ≥ 2 or ≤ 0.5 and P ≤ 0.05). Target gene prediction and KEGG enrichment analysis revealed that all of the target genes were concentrated in 13 pathways associated with immune response, including the mTOR signaling pathway and the TGF-beta signaling pathway. The expression patterns of 8 differentially expressed genes and 4 miRNAs involved in immune response were validated by quantitative real-time RT-PCR. These results provide insights into the molecular mechanisms underlying the effects of bacterial haemorrhagic septicemia on the immune response of Leiocassis longirostris.

2020-01-30 | GSE138968 | GEO

Effects of bacterial haemorrhagic septicemia on the immune response of Leiocassis longirostris (RNA-Seq)

2020-01-30 | GSE138967 | GEO

Effects of bacterial haemorrhagic septicemia on the immune response of Leiocassis longirostris

Project description:Effects of bacterial haemorrhagic septicemia on the immune response of Leiocassis longirostris

| PRJNA577904 | ENA

Effects of bacterial haemorrhagic septicemia on the immune response of Leiocassis longirostris (microRNA-Seq)

Project description:Effects of bacterial haemorrhagic septicemia on the immune response of Leiocassis longirostris (microRNA-Seq)

| PRJNA577905 | ENA

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Project description:Leiocassis longirostris Genome sequencing and assembly

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Leiocassis longirostris strain:LELOWH01

Project description:Leiocassis longirostris genome sequencing

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Effects of bacterial haemorrhagic septicemia on the immune response of Leiocassis longirostris

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-01-29 | GSE138969 | GEO

Leiocassis longirostris strain:LELOWH01

Project description:The Chinese longsnout catfish, Leiocassis longirostris, is a semi-migratory and valuable freshwater fish native to China.

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Zebrafish early transcriptional response to viral haemorrhagic septicemia rhabdovirus (VHSV) challenge vs2

Project description:We describe here the transcripts induced after infection of zebrafish with viral haemorrhagic septicemia rhabdovirus (VHSV). Two days after infection, differentially expressed transcript levels from selected immune-related zebrafish genes were studied in both fins and internal organs (pooled spleen, head kidney and liver).

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